Developing microemulsion containing memantine as transdermal drug delivery system for treatment of Alzheimer disease
Other Title(s)
تطوير مستحلب دقيق يحتوي على دواء الميمانتين بغرض التطبيق عن طريق الجلد لعلاج مرض الزهايمر
Dissertant
Yunus, Baha al-Din Mahmud Yusuf
Thesis advisor
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2022
English Abstract
The oral administration of memantine as an anti-Alzheimer disease (AD) is associated with many side effects.
In this study, new nonionic microemulsion containing memantine to target the brain via transdermal administration was evaluated compared to oral solution.
The microemulsions were tested for physical characteristics such as rheological behaviour, droplet size and drug loading.
In addition, the skin permeability was evaluated in vitro using Franz diffusion cells.
Moreover, LC-MSMS was used to measure the plasma level and drug concentration in the brain after transdermal administration compared to oral administration.
The loaded memantine microemulsion showed Newtonian viscosity and droplet size below 100 nm.
Besides, a flux value as high as 0.6819 ±0.04873 mg/cm2 h using ME2 (microemulsion) could be achieved.
Furthermore, the estimated bioavailability was as follows 81.14% for transdermal administration.
Moreover, the oral showed faster absorption than transdermal absorption.
Also, transdermal showed a higher plasma concentration (Cmax 318.028 ng/h).
And it had a higher mean residence time (11.345 h) and had the most constant level in plasma and brain.
Transdermal had a longer half-life (15.62 h) than oral.
The difference in brain level was found to be significant between oral solution and transdermal ME2.
The loaded MEs are stable colloidal drug delivery systems that are potential carriers for transdermal administration to control the plasma level and reduce the side effects associated with oral administration.
Based on these findings, it is reasonable to suggest that memantine-loaded microemulsion could be a promising approach for Alzheimer’s disease as a transdermal drug delivery system.
Main Subjects
No. of Pages
71
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Previous studies about transdermal administration of memantine.
Chapter Three : Materials, methods, and instruments.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion and recommendations.
References.
American Psychological Association (APA)
Yunus, Baha al-Din Mahmud Yusuf. (2022). Developing microemulsion containing memantine as transdermal drug delivery system for treatment of Alzheimer disease. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414454
Modern Language Association (MLA)
Yunus, Baha al-Din Mahmud Yusuf. Developing microemulsion containing memantine as transdermal drug delivery system for treatment of Alzheimer disease. (Master's theses Theses and Dissertations Master). Isra University. (2022).
https://search.emarefa.net/detail/BIM-1414454
American Medical Association (AMA)
Yunus, Baha al-Din Mahmud Yusuf. (2022). Developing microemulsion containing memantine as transdermal drug delivery system for treatment of Alzheimer disease. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414454
Language
English
Data Type
Arab Theses
Record ID
BIM-1414454
