Synthesis of some (4-Hydroxyphenyl) acetic acid prodrugs to improve anxiolytic activity
Other Title(s)
تخليق بعض الأدوية الأولية لحمض الخليك (4-هيدروكسيفينيل) لتحسين مزيل القلق
Dissertant
Thesis advisor
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2022
English Abstract
Background: Anxiety disorders are mental health conditions with a feeling of worry or fear, Current medication available in the market has suboptimal efficiency and tolerability which highlights the need for developing new drug treatments (Beck et al., 1988).
The 4- Hydroxylphenylacetic acid (4-HPAA) is a natural compound found in biological sources.
The 4- HPAA level has been linked to psychological disorders such as anxiety and depression (Sandler et al., 1979).
The previous pharmacokinetic studies demonstrated 4-HPAA has suboptimal pharmacokinetic including rapid elimination and difficulty in absorption (Zabela et al., 2016a).
Methods: In this study synthesis of 4-HPAA derivatives such as Isopropyl 4-Hydroxyphenyl acetate (IHPA), Isopropyl 4-Methoxyphenyl acetate (IMPA), and 4-Methoxyphenylacetic acid (4- MPAA) and evaluation anxiolytic activity by Elevated plus-maze test (EPM), Elevated zero maze test (EZM), and locomotor activity by Actophotometer test in mice.
Results: These efforts are indicative of 4-HPAA not being considered as an anxiolytic compound.
Isopropyl (4-Hydroxyphenyl) acetate and Isopropyl (4-Methoxyphenyl) acetate may suggest anxiolytic properties.Conclusion: In this study Isopropyl 4-Hydroxyphenyl acetate and Isopropyl 4-Methoxyphenyl acetate are possible prodrugs that undergo metabolic activation before becoming physiologically active.
Our hypothesis 4-HPPA convert to lipophilic prodrug to improved permeability through the blood-brain barrie for enhancing anxiolytic effect.
Main Subjects
No. of Pages
67
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Methodology.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion.
References.
American Psychological Association (APA)
al-Husayni, Kawthar Uthman. (2022). Synthesis of some (4-Hydroxyphenyl) acetic acid prodrugs to improve anxiolytic activity. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414533
Modern Language Association (MLA)
al-Husayni, Kawthar Uthman. Synthesis of some (4-Hydroxyphenyl) acetic acid prodrugs to improve anxiolytic activity. (Master's theses Theses and Dissertations Master). Isra University. (2022).
https://search.emarefa.net/detail/BIM-1414533
American Medical Association (AMA)
al-Husayni, Kawthar Uthman. (2022). Synthesis of some (4-Hydroxyphenyl) acetic acid prodrugs to improve anxiolytic activity. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1414533
Language
English
Data Type
Arab Theses
Record ID
BIM-1414533
