Moringa peregrina leaf extracts produce anti-obesity, hypoglycemic, anti-hyperlipidemic, and hepatoprotective effects on high-fat diet fed rats
Joint Authors
al-Shammari, Ghadir M.
al-Maiman, Salah Abd al-Muhsin
al-Khudayri, Dalal A.
Yahya, Muhammad Abduh
Uthman, Majdi Abd al-Wahhab
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 6 (30 Jun. 2021), pp.3333-3342, 10 p.
Publisher
Publication Date
2021-06-30
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Abstract EN
This present research investigated the anti-obesity and hepatoprotective effects of ethanolic moringa peregrina leaf (MPLE) and bark extracts (MPBE), in the rats fed with a high-fat diet (HFD).
Healthy male rats (n = 48) were randomly distributed to six groups (n = 8): control AIN-93 diet; HFD; HFD + MPBE bark extracts ((300 mg/kg); HFD + MPBE (600 mg/kg); HFD + MPLE (300 mg/kg); HFD + MPLE (600 mg/kg).
HFD-fed rats in the Moringa peregrina (MP) treatment groups received orally administered MP leaf or bark extract daily for eight weeks.
the results revealed that both doses of MP leaf extract significantly reduced HFD-induced increases in their food intake and the gained body weight, fat pad weights (visceral, subcutaneous, and epididymal), glucose and insulin plasma levels, and leptin and resistin serum levels in HFDfed rats.
concomitantly, MP leaf extract improved glucose levels after oral or intraperitoneal glucose tolerance tests, reduced serum cholesterol, triglycerides, and the low-density lipoprotein LDL concentration, reduced hepatic triglycerides and cholesterol levels, and increased serum high-density lipoproteins HDL levels and triglycerides and cholesterol levels in fecal.
moreover, the administration of MPLE to HFD-fed rats improved liver architecture, reduced fat accumulation, reduced hepatic malondialdehyde, tumor necrosis factor-a, and interleukin-6 levels.
hepatic glutathione peroxidase, superoxide dismutase, and catalase activities were significantly increased.
all observed effects were more pronounced in HFD-fed rats treated with a 600 mg/kg MP dose.
However, neither dose of MPBE altered the measured markers in the HFD-fed rats.
In conclusion, MPLE showed potential anti-obesity and hepatoprotective activity in HFD-induced obese rats, mediated by reduced lipid absorption, anti-hyperlipidemic effects, and hepatic antioxidant effects.
American Psychological Association (APA)
al-Khudayri, Dalal A.& Uthman, Majdi Abd al-Wahhab& al-Shammari, Ghadir M.& al-Maiman, Salah Abd al-Muhsin& Yahya, Muhammad Abduh. 2021. Moringa peregrina leaf extracts produce anti-obesity, hypoglycemic, anti-hyperlipidemic, and hepatoprotective effects on high-fat diet fed rats. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3333-3342.
https://search.emarefa.net/detail/BIM-1415255
Modern Language Association (MLA)
al-Khudayri, Dalal A.…[et al.]. Moringa peregrina leaf extracts produce anti-obesity, hypoglycemic, anti-hyperlipidemic, and hepatoprotective effects on high-fat diet fed rats. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3333-3342.
https://search.emarefa.net/detail/BIM-1415255
American Medical Association (AMA)
al-Khudayri, Dalal A.& Uthman, Majdi Abd al-Wahhab& al-Shammari, Ghadir M.& al-Maiman, Salah Abd al-Muhsin& Yahya, Muhammad Abduh. Moringa peregrina leaf extracts produce anti-obesity, hypoglycemic, anti-hyperlipidemic, and hepatoprotective effects on high-fat diet fed rats. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3333-3342.
https://search.emarefa.net/detail/BIM-1415255
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3341-3342
Record ID
BIM-1415255