In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts
Joint Authors
Khan, Muhammad Naim Allah
Umran, Muhammad
Faisal, Shah
Jan, Hasanayn
Shah, Sajjad Ali
Shah, Sumairah
Akbar, Muhammad Taj
Jan, Fahim
Sayyid, Sulayman
Radwan, Muhammad
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 5 (31 May. 2021), pp.3031-3036, 6 p.
Publisher
Publication Date
2021-05-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Sociology and Anthropology and Social Work
Abstract EN
This research study is mainly focused to evaluate the anti-parasitic, insecticidal, cytotoxic and anti- alzheimer potential of various leaf extracts of Ajuga bracteosa Wallich ex Bentham.
04 different extracts were prepared using solvent of different polarity to determine the best candidate for potent bioactivity i.e.
n-hexane (NH), Ethyl acetate (EA), Ethanol (EL) and Chloroform (CH).
Concentrations of each extracts were made specified for all activities.
All extracts were exploited for broad range of biomedical applica- tions including leishmaniasis, in vitro anti-Alzheimer, insecticidal and cytotoxic studies.
Our results showed that A.
bracteosa n-hexane extract was highly active against Leishmania Tropica with significant inhibition of 58 ± 1.61 for promastigote and 63 ± 2.29 for amastigote at 1000 lg/mL.
Furthermore, promising anti-alzheimer activity acetylcholinesterase (AChE) 46 ± 0.83 and butrylcholineterase (BChE) 49 ± 1.17 was noted for n-hexane.
The insecticidal potential of these extracts were test against five different insects (Rhyzopertha dominica, Trogoderma granarium, Tribolium castaneum, Sitophilus oryze, and Callosobruchus analis).
The higest mortality rate of insecticidal activity was recorded by n-hexane fol- lowed by Ethyl acetate whereas ethanol extract was found to be less effective against all the test species.
Significant cytotoxic potential of each plant sample against Artemia salina thus aware us for further detailed research to find out novel drugs.
Based on our results we believe that Ajuga bracteosa could be used to develop as a potential botanical insecticide against different insect and pests, such as aphids as well as an excellent source for the compound isolation as anti-tumor agent.
American Psychological Association (APA)
Umran, Muhammad& Jan, Hasanayn& Faisal, Shah& Shah, Sajjad Ali& Shah, Sumairah& Khan, Muhammad Naim Allah…[et al.]. 2021. In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.3031-3036.
https://search.emarefa.net/detail/BIM-1419241
Modern Language Association (MLA)
Umran, Muhammad…[et al.]. In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.3031-3036.
https://search.emarefa.net/detail/BIM-1419241
American Medical Association (AMA)
Umran, Muhammad& Jan, Hasanayn& Faisal, Shah& Shah, Sajjad Ali& Shah, Sumairah& Khan, Muhammad Naim Allah…[et al.]. In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.3031-3036.
https://search.emarefa.net/detail/BIM-1419241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3035-3036
Record ID
BIM-1419241