Synthesis of methyl-[2-(2,6-dichloro-N-ethyl anilino) phenyl] acetate starting from diclofenac sodium and confirm its structure by spectroscopic methods
Other Title(s)
اصطناع ميثيل [2-(62- ثنائي كلورو-N-ايثيل أنيلينو) فينيل] أسيتات انطلاقا من ديكلوفيناك الصوديوم و التأكد من بنيته باستخدام الطرق الطيفية
Joint Authors
Source
Arab Journal for Pharmaceutical Sciences
Issue
Vol. 6, Issue 5 (31 Dec. 2020), pp.90-96, 7 p.
Publisher
Publication Date
2020-12-31
Country of Publication
Syria
No. of Pages
7
Main Subjects
Abstract EN
Diclofenac is one of the moft NSAIDs used in the treatment of a wide range of disease conditions, due to its availability in various pharmaceutical forms, well tolerability and high efficiency as an analgesic, antipyretic, and anti-inflammatory agent.
However, it does shows serious side effects in the long term of treatment that could be life threatening in some cases.
Therefore, it was necessary to search for a novel, safer and more potent derivatives.
In this research, a new derivative of diclofenac was synthesized, by an alkyla-tion process of the aromatic secondary amine group in the methyl efter of diclofenac, using ethyl bromide under appropriate conditions with a good yield, and the ftructure of the new N-ethyl derivative was checked using FTIR and NMR spectroscopy.
All the spectral data correspond and indicate .to the entry of ethyl group and thus the completion of N-alkylation process
American Psychological Association (APA)
Mustafa, Rim& Harbali, Jihad. 2020. Synthesis of methyl-[2-(2,6-dichloro-N-ethyl anilino) phenyl] acetate starting from diclofenac sodium and confirm its structure by spectroscopic methods. Arab Journal for Pharmaceutical Sciences،Vol. 6, no. 5, pp.90-96.
https://search.emarefa.net/detail/BIM-1424455
Modern Language Association (MLA)
Mustafa, Rim& Harbali, Jihad. Synthesis of methyl-[2-(2,6-dichloro-N-ethyl anilino) phenyl] acetate starting from diclofenac sodium and confirm its structure by spectroscopic methods. Arab Journal for Pharmaceutical Sciences Vol. 6, no. 5 (Dec. 2020), pp.90-96.
https://search.emarefa.net/detail/BIM-1424455
American Medical Association (AMA)
Mustafa, Rim& Harbali, Jihad. Synthesis of methyl-[2-(2,6-dichloro-N-ethyl anilino) phenyl] acetate starting from diclofenac sodium and confirm its structure by spectroscopic methods. Arab Journal for Pharmaceutical Sciences. 2020. Vol. 6, no. 5, pp.90-96.
https://search.emarefa.net/detail/BIM-1424455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 96
Record ID
BIM-1424455