Potential protective effects of lemon verbena (aloysia citriodora)‎ leaves against gastric ulcer in rats: biological, biochemical and technological studies

Abstract EN

Lemon verbena (Aloysia citriodora) is an herb characterized by containing a large amount of phenols such as flavonoids and phenylpropanoids, which have been found to play an effective role in controlling digestive disorders.

so that, this study sought to evaluate the gastroprotective properties of lemon verbena against stomach ulcers in rats induced by ethanol.

randomly, thirty male albino rats were divided into five groups (6 / each).

rats were injected with ethanol to induce stomach ulcers.

the antiulcer activity of lemon verbena leaves ethanol extract (LVEE) were estimated at different doses (50 and 100 MG / KG body weight) and compared with omeprazole (OMZ) which used as a standard drug at dose (40 MG / KG body weight).

to find out the possible mechanisms of action, data of the present study estimated the levels of oxidative stress parameters.

gastric juice volume, PH, and other stomach ulcer examinations as well as histological examination of gastric ulcers were done.

rats that were given ethanol only (positive group) showed significant elevations in ulcer score, ulcer index (UI) and decreases antioxidant enzymes.

moreover, the levels of malonaldehyde (MDA) remarkably increased in the positive group compared to the negative group.

the pretreatment of rats with LVEE at different dose levels not only improved stomach ulcer measurements and the activities of antioxidants but also significantly reduced the concentration of MDA in stomach tissues.

these results confirm that LVEE has gastroprotective properties by stimulating antioxidant enzymes.

finally, lemon verbena leaves powder has been used in bread flour with the goal of producing a fortified bread that can be recommended for stomach ulcer patients.