Prevalence of congenital cytomegalovirus infection among hospitalized neonates in Tehran, Iran
Joint Authors
Ridai, Farhad
Jumah, Husam al-Din Imam
Farahmand, Majid
Haghighi, Fayizah
Izadpanahi, Maryam
Nurbakhsh, Samileh
Farhadi, Muhammad
Hasanabad, M. Haghighi
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 10 (31 Oct. 2020), pp.1-6, 6 p.
Publisher
Publication Date
2020-10-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background: Cytomegalovirus (CMV) can vertically transmit from infected mothers to fetuses and causes congenital infection in newborns.
Unfortunately, there have been limited data available on the prevalence of congenital CMV (cCMV) infection among Iranian neonates at higher risk of infection.
Objectives: The current study aimed to assess the prevalence of cCMV infection among hospitalized neonates in Tehran, Iran, and investigate the diagnostic values of CMV polymerase chain reaction (PCR) on Guthrie cards in comparison to those reported for urine specimens.
Methods: This cross-sectional study was carried out on the hospitalized neonates with 3 weeks of age.
The urine specimens and Guthrie cards were taken from each eligible newborn.
Total nucleic acid was extracted from the samples and tested by PCR for the presence of CMV deoxyribonucleic acid.
The cCMV infection was confirmed in the newborns, and the infected neonates underwent further evaluation.
Results: Out of 224 newborns, CMV infection was identified in 11 neonates (4.9%).
There were no factors in association with cCMV infection.
The sensitivity and specificity of dried blood spot (DBS) samples for the identification of newborns with cCMV infection were 90% and 99%, respectively.
Conclusion: A significant number of hospitalized neonates in the present study were infected with cCMV infection.
The results of the current study revealed that Guthrie cards had adequate sensitivity for the identification of CMV infection in the hospitalized newborns.
Since symptomatic newborns with cCMV infection have a higher chance for the development of early- or late-onset sequelae of infection, it is recommended to diagnose and treat this group of newborns.
American Psychological Association (APA)
Farhadi, Muhammad& Ridai, Farhad& Jumah, Husam al-Din Imam& Farahmand, Majid& Haghighi, Fayizah& Izadpanahi, Maryam…[et al.]. 2020. Prevalence of congenital cytomegalovirus infection among hospitalized neonates in Tehran, Iran. Iranian Red Crescent Medical Journal،Vol. 22, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-1430684
Modern Language Association (MLA)
Farhadi, Muhammad…[et al.]. Prevalence of congenital cytomegalovirus infection among hospitalized neonates in Tehran, Iran. Iranian Red Crescent Medical Journal Vol. 22, no. 10 (Oct. 2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1430684
American Medical Association (AMA)
Farhadi, Muhammad& Ridai, Farhad& Jumah, Husam al-Din Imam& Farahmand, Majid& Haghighi, Fayizah& Izadpanahi, Maryam…[et al.]. Prevalence of congenital cytomegalovirus infection among hospitalized neonates in Tehran, Iran. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-1430684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-1430684