Efficacy of intra articular botulinum toxin injection in sickle cell patients’ joints
Joint Authors
Turani, Badriyah
Ahmad, Uways
al-Mashhur, Mutasim
al-Mansuri, Nada
Ashri, Shakir
Source
Journal of the Bahrain Medical Society
Issue
Vol. 32, Issue 3 (30 Sep. 2020), pp.1-8, 8 p.
Publisher
Publication Date
2020-09-30
Country of Publication
Bahrain
No. of Pages
8
Main Subjects
Abstract EN
Background: Sickle cell disease patients have a tendency for vaso-occlusive attacks involving their bones.
Osteonecrosis results in infarction of the articular surfaces and heads of long bones, leading to chronic joint pain, significant interference in functioning and quality of life.
Intraarticular Botox injection is safe andreduces chronic pain while patients’ mobility.
Objective: The study aimed to evaluate the symptomatic change and its duration after intra-articular Botox injection, in sickle cell disease patients with chronic pain.
Methods: Sickle cell disease patients with chronic joint pain observed at Salmaniya medical complex were included.
Patients were injected with Botox intraarticularly and followed up for a year.Symptomatic parameters were assessed at every follow- up, raw data collected was entered into Microsoft Excel spreadsheet were the numerical variables analyzed and graphs were created.
Results: Forty-eight sickle cell disease patients were included.Postthe intraarticular injection at 3 months, the level of pain according to, Numerical rating scale (NRS) reduced by 44.6 % (p-value <0.005) and 27.8%( p-value < 0.001) at 6 months and 9.54% ( p-value <0.01) at 1 year, and significant improvement of other parameters.
Conclusion: Intraarticular BoNT/ A injection provides an alternative treatment in sickle disease patients with good results in reduction of pain, improved physical function, mood, and sleep pattern lasting at least 6 months.
Although a small scale study, the results suggest that BoNT/ A is an effective and safe treatment.
American Psychological Association (APA)
al-Mashhur, Mutasim& Turani, Badriyah& al-Mansuri, Nada& Ashri, Shakir& Ahmad, Uways. 2020. Efficacy of intra articular botulinum toxin injection in sickle cell patients’ joints. Journal of the Bahrain Medical Society،Vol. 32, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-1437573
Modern Language Association (MLA)
al-Mashhur, Mutasim…[et al.]. Efficacy of intra articular botulinum toxin injection in sickle cell patients’ joints. Journal of the Bahrain Medical Society Vol. 32, no. 3 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1437573
American Medical Association (AMA)
al-Mashhur, Mutasim& Turani, Badriyah& al-Mansuri, Nada& Ashri, Shakir& Ahmad, Uways. Efficacy of intra articular botulinum toxin injection in sickle cell patients’ joints. Journal of the Bahrain Medical Society. 2020. Vol. 32, no. 3, pp.1-8.
https://search.emarefa.net/detail/BIM-1437573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-1437573