Nephroprotective effect of clove (syzygium aromaticum)‎ extract on carbon tetrachloride induced nephrotoxicity in albino rats

Abstract EN

Exposure to carbon tetrachloride (CCL4) inhibits acute and continual renal injuries besides oxidative stress in rats.

The present investigation was carried out in an attempt to assess the nephroprotective potential of clove (Syzygium aromaticum) extract (CE) towards CCL4 precipitated nephrotoxicity.

Forty adult male Wister albino rats weighing 140-180g and divided into four groups, each group (10) rats.

Group (1): normal rats served as the negative control group; group (2): rats implemented with CE (50 mg/kg/day) orally; group (3): rats injected with CCL4 (0.5 mg/kg/ two times weekly) intraperitoneal, and group (4): rats inflamed with CCL4 and treated with CE.

After six weeks, the results revealed that CE and CCL4 minimized the CCL4-induced renal deterioration; this was evidenced by the significant reduction in urea, creatinine, uric acid, TNF-α, IL-1β, and Na, as well as kidney MDA.

This is matched with a marked enhancement in serum calcium, K, and CD4 levels and kidney GSH and CAT levels.

In conclusion, Clove (Syzygium aromaticum) extract can be as promising as nephroprotection in opposition to CCL4 nephrotoxicity through their antioxidant and radical scavenging activities.