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Proteinuria in adult Saudi patients with sickle cell disease is not associated with identifiable risk factors
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 5 (31 Oct. 2010), pp.903-908, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-10-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Renal involvement in patients with sickle cell disease (SCD) is associated with significant morbidity and mortality.
Proteinuria is common in patients with SCD and is a risk factor for future development of renal failure.
We sought to identify risk factors, if any, associated with proteinuria in adult Saudi patients with SCD.
We studied 67 patients with SCD followed-up at the King Khalid University Hospital, Riyadh, Saudi Arabia.
All patients underwent 24-hour urine collection to measure creatinine clearance and to quantify proteinuria.
In addition, blood was examined for evaluation of hematological and biochemical parameters.
Clinical information was gathered from review of the patients' charts.
A urine protein level of more than 0.150 grams/24 hours was considered abnormal.
Urine protein was correlated with various clinical and laboratory parameters.
Thirtyone males and 36 females were evaluated.
The mean age of the cohort was 23.8 (± 7.2) years.
Twenty-seven patients (40.3%) had proteinuria of more than 0.150 grams/24 hours.
The study group had a mean hemoglobin level of 8.5 (± 2.8) g/dL and mean fetal hemoglobin (HbF) level of 14.4% (± 7.3%).
Majority of the patients (61) had hemoglobin SS genotype and six patients had S-?0 thalassemia.
None of the parameters evaluated correlated with proteinuria although there was a borderline association with older age and higher systolic blood pressure (P = 0.073 and 0.061 respectively).
Hydroxyurea use for more than a year was not beneficial.
In conclusion, our study suggests that proteinuria in adult Saudi patients is not associated with any clear identifiable risk factors.
American Psychological Association (APA)
Alim, Amir. 2010. Proteinuria in adult Saudi patients with sickle cell disease is not associated with identifiable risk factors. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 5, pp.903-908.
https://search.emarefa.net/detail/BIM-216680
Modern Language Association (MLA)
Alim, Amir. Proteinuria in adult Saudi patients with sickle cell disease is not associated with identifiable risk factors. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 5 (Oct. 2010), pp.903-908.
https://search.emarefa.net/detail/BIM-216680
American Medical Association (AMA)
Alim, Amir. Proteinuria in adult Saudi patients with sickle cell disease is not associated with identifiable risk factors. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 5, pp.903-908.
https://search.emarefa.net/detail/BIM-216680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 907-908
Record ID
BIM-216680