Pattern of glomerular diseases in Sudanese children : a clinico-pathological study
Joint Authors
Abd al-Rahim, Muhammad B.
al-Tijani, M. A. Ali
Muhammad, Rim M.
Hassan, Inas G.
Makki, Salwa O.
Yusuf, B. M.
Abd Allah, Usamah Ali Muhammad
Watson, Alan R.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 4 (30 Aug. 2010), pp.778-783, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-08-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Glomerular diseases are a common cause of chronic kidney disease (CKD) in many countries.
The pattern of glomerular diseases has been reported in adult Sudanese patients but there has been no previous study on Sudanese children.
The aim of this study is to describe the pattern of glomerular diseases in Sudanese children from a clinico-pathological perspective.
We retrospectively reviewed the clinical records of 321 children seen with nephritis/nephrosis at the Pediatric Nephrology Unit, Soba University Hospital and Dr.
Salma Dialysis and Kidney Transplantation Centre, Khartoum, Sudan during the period from 2002 to 2007.
Biopsies were studied with light microscopy and immunohistochemistry with electron microscopy performed abroad in selected patients (predominantly Alport's).
The mean age of the 321 study children was 8.71 years (range 2 months-16 yrs) of whom, 188 were males (60.2%).
The most common presentation was with the nephrotic syndrome, seen in 202 patients (62.9%).
The most common glomerular disease encountered was minimal change disease, seen in 96 children (29.9%), followed by post-infectious GN in 78 (24.3%) and focal and segmental glomerulosclerosis, seen in 44 patients (13.7%).
Membranoproliferative GN (MPGN) was seen in 43 patients (13.4%) while mesangioproliferative GN was seen in 24 (7.5%).
Systemic lupus erythematosus (SLE) was the most common secondary glomerular disease accounting for 16 patients (4.9%).
HBsAg was positive in 10 patients and the most common associated lesion was MPGN (60%).
Histopathology enabled us to change the therapy in 55.3% of the patients.
Our study suggests that the pattern of GN in our cohort of patients is comparable with reports from other parts of the world with a high prevalence of post-infectious GN.
Renal biopsies have an important part in planning therapy and management.
Also, the importance of establishing a Sudanese renal registry including pediatric patients is stressed.
American Psychological Association (APA)
Abd al-Rahim, Muhammad B.& al-Tijani, M. A. Ali& Muhammad, Rim M.& Abd Allah, Usamah Ali Muhammad& Makki, Salwa O.& Yusuf, B. M.…[et al.]. 2010. Pattern of glomerular diseases in Sudanese children : a clinico-pathological study. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 4, pp.778-783.
https://search.emarefa.net/detail/BIM-219680
Modern Language Association (MLA)
Abd al-Rahim, Muhammad B.…[et al.]. Pattern of glomerular diseases in Sudanese children : a clinico-pathological study. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 4 (Sep. 2010), pp.778-783.
https://search.emarefa.net/detail/BIM-219680
American Medical Association (AMA)
Abd al-Rahim, Muhammad B.& al-Tijani, M. A. Ali& Muhammad, Rim M.& Abd Allah, Usamah Ali Muhammad& Makki, Salwa O.& Yusuf, B. M.…[et al.]. Pattern of glomerular diseases in Sudanese children : a clinico-pathological study. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 4, pp.778-783.
https://search.emarefa.net/detail/BIM-219680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 782-783.
Record ID
BIM-219680