Effect of selenium on antioxidant status, lipid per oxidation, enzyme activities and biochemical parameters in ccl4-induced experimental liver injury in rats

Abstract EN

The objective of the present study was to investigate the role of selenium on carbon tetrachloride (CCl4)-induced toxicity in male Wistar rats.

Significant (P<0.05) elevated mean levels of malondialdehyde (MDA) and lowered mean levels of total antioxidant capacity were observed in plasma of CCl4-induced rats when compared to values in normal control.

The activities of aspartate aminotransferase (AST), and alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH) were significantly (P<0.05) increased in plasma of CCl4-induced rats.

Also, significant (P<0.05) increase in the mean values of total cholesterol (TC), urea, creatinine and total bilirubin (Tb) were observed in plasma of CCl4-induced rats compared to the values in normal control, whereas, significant (P<0.05) decrease in the mean values of total lipids (TL), total protein, and albumin were recorded in the plasma of CCl4-injected rats.

All enzyme activities and blood parameters as well as lipid peroxides (MDA) and total antioxidant capacity in CCl4 group injected with selenium were arranged to comparable values to those of control group.

In conclusion, it is suggested that selenium application is able to antagonize the oxidative damage caused by CCl4 (at 0.15 ml/kg body weight) in liver and kidney of Wistar rats.