The effect of propolis extract supplement on the prevention of heart

Abstract EN

A natural product propels is commonly used as a folk remedy.

It contains various chemical components and exhibits a broad spectrum of biological activities, including antibacterial, anticancer and antioxidant activities.

Anthracyclines, potent anticancer drugs, are effectives against a wide range of human neoplasms but their use has been limited by their toxicity.

The precise molecular mechanism of doxorubicin induced cardio toxicity is still not well understood but it has been suggested that mitochondria plays a central role in this process by free radical generation.

The purpose of this research was to investigate the protective mechanisms of propels extract against doxorubicin (10M) cardio toxicity.

The ant apoptotic effect of propels extract on myocardia cells in culture treated by anticancer drugs at 20mg / Kg was analysed.

Its long term oral administration effect at 100 mg / Kg daily for 60 days on rat heart and vascular tissues was also evaluated.

The in vitro study was carried using culture cells (cardiomyocyts) and heart mitochondria isolated from rat.

Capsizes 3 and 9 activities, glutathione concentration, respiratory control ratio (RCR), superoxide radical production and lipid peroxidation were measured.

The results revealed the protective effect of propel extract against doxorubicin induced cardio toxicity.

It restored the cardiovascular functions and reduced the toxic effect of the drug.

Doxorubicin induced apoptosis was corrected entirely.

Decrease in lipid peroxidation, an increase in glutathione concentration and a restoration of mitochondrial functions and potential membrane altered by doxorubicin both in heart and vascular tissues were also noted.

The long term treatment with propels extract suggested that Algerian propels has no side effects and can be used as a dietary supplement for cardiovascular risk prevention.