Effects of garlic oil and vitamin c on some erythrocytes and brain antioxident enzymes and immunoglobulins in healthy and hyperlipidemic rats

Abstract EN

Five groups of eight albino rats were studied.

Group (I), control normal rats fed ordinary rat diet.

Group (II), fed a hyperlipidemic diet (hyperlipidemic control).

Group (III), hyperlipidemic rats administrated garlic oil (28-mg/kg-body wt.

Orally).

Group (IV), hyperlipidemic rats administrated vitamin C (18mg/ kg-body wt.).

Group (V), hyperlipidemic rats administrated garlic oil and vitamin C by the same previous doses.

Blood and brain samples were collected at 2 and 4 weeks after administration of garlic oil and vitamin C.

The recorded data revealed highly significant (p<0.05) increase in glutathione peroxidase (GSH-Px), and glutathione-S-transferase (GST), while there are significant decreases in glutathione reductase (GR-ase), reduced glutathione (GSH), and total superoxide dismutase (t-SOD) in the hyperlipidemic group.

The administration of garlic oil and vit.

C reverse that effect in hyperlipedemic group.

Regarding the brain extract there is a significant decrease in the activities of t-SOD, catalase and GSH, while there is a significant increase in the activity of GSH-Px in the hyperlipidemic rats.These values returned to normal after garlic oil and vit.

C administration.

There is a non significant change in plasma immunoglobulins (IgG, IgA and IgM) concentrations in all groups allover the experimental periods