Equivalent inhibition of serum and Hhepatic lipid profile and lipid peroxidation by two different doses of green tea in rats fed a high cholesterol diet

Abstract EN

The aim of the present investigation was to study the equivalent inhibition of lipid profile and lipid peroxidation by different doses of green tea in Wister rats fed a high-cholesterol diet (HCD).

Hypercholesterolemia was induced in male albino Wister rats by feeding them with a HCD for 35 days.

The experimental rats were given two different doses of green tea (GT) as a supplement via drinking water.

The obtained results indicated that a significant increase in serum and hepatic total cholesterol, triglycerides, and serum low density lipoprotein (LDL) cholesterol while a decrease high density lipoprotein (HDL) cholesterol was observed in HCD fed rats, along with elevated levels of lipid peroxidation (LPO) in serum and hepatic tissue, with a concomitant increase in the body weight, food intake, and food efficiency.

Treatment with green tea (7 g/L) or (14 g/L) resulted in a decrease in serum and hepatic total cholesterol and triglycerides and lipid peroxidation.

Moreover, significant decrease in the serum and hepatic LPO, body weight gain and food efficiency were observed in both doses i.e., (7 or 14 g/L) of GT group when compared with control and HCD fed groups.

Interestingly, supplementation with the high dose of GT (14 g/L) was not more effective than low dose (7 g/L) to rats fed HCD resulted in decreased levels of lipid profile and lipid peroxidation.

Therefore, the results suggest that both doses of GT confer protection against the development of hypercholesterolemia in rats.

Thus, low dose of GT may be enough to provide a good beneficial response.