Hx and K^- blocking activity of 1-p- chloroaryl-1- hydroxy-2- (N, N- dibenzylamino)‎ ethane and 1-p- bromoaryl-1- hydroxy-2- (N, N- dibenzylamino)‎ ethane

Abstract EN

The two compounds, l-p-choroaryl-l-hydroxy-2-(N, N-dibenzyl amino) ethane and l-p-bromoaryl-l-hydroxy-2-(N, N-dibenzylamino) ethane, were investigated in contracting rat uterus, aspirin-induced ulcer in rat stomach, right atrium of guinea pig to show their H2-receptor blocking activity, and in guinea pig ileum for Hi-antihistarninic activity; results were compared with the standard Hi- and H2-blockers.

Both compounds produced reduction of aspirin-induced ulcer lesions in rat stomach, blocked completely the relaxant response of histamine in contracting rat uterus, blocked completely the stimulatory action of histamine on right atrium of guinea pig and brought the heart to its normal rate, also blocked completely the contraction induced by histamine in guinea pig ileum.

It is concluded that the two compounds tested biologically in vivo and vitro showed prolonged H2-receptors blocking activity and Hi-receptors anti-histaminic activity.