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Kinetics of eosinophilia and IGE production in experimental murine toxocariasis
Joint Authors
Hafiz, Adil Umar
al-Shazli, Atif M.
al-Shaykhah, Hani M.
Mursi, Tusun Ali
al-Beshbishi, Samar N.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 1 (30 Apr. 2008), pp.53-64, 12 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Eosinophilia and immunoglobulin E (IgE) antibody are considered the first and important elements in host responses to helminth in-fection.
Toxocara canis, which elicits prominent eosinophilia and IgE production in normal mice, may be useful in understanding the kinetics of circulating peripheral blood eosinophils and IgE antibody during infection.
The onset, magnitude and duration of peripheral blood eosinophilia and total IgE production after primary T.
canis in-fection in female outbred albino mice was investigated.
Mice were either sham inoculated (controls) or were orally infected with 1000 embryonated eggs of T.
canis.
Patterns in leucocytic changes include significant increase in total WBC count between weeks 6 and 13 post infection (PI) with a peak on week 8 PI.
Mice showed eosinophilia between weeks 2 to 17 PI with a peak on week 7.
The development of eosinophilia in T.
canis-infected mice was accompanied by the relea-se of prominent level of serum IgE between weeks 2 to 21 with a peak at week 6 PI.
These findings showed that eosinophilia in T.
canis infected outbred mice can be T-cell dependent.
American Psychological Association (APA)
al-Shaykhah, Hani M.& al-Beshbishi, Samar N.& al-Shazli, Atif M.& Hafiz, Adil Umar& Mursi, Tusun Ali. 2008. Kinetics of eosinophilia and IGE production in experimental murine toxocariasis. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 1, pp.53-64.
https://search.emarefa.net/detail/BIM-280141
Modern Language Association (MLA)
al-Shaykhah, Hani M.…[et al.]. Kinetics of eosinophilia and IGE production in experimental murine toxocariasis. Journal of the Egyptian Society of Parasitology Vol. 38, no. 1 (Apr. 2008), pp.53-64.
https://search.emarefa.net/detail/BIM-280141
American Medical Association (AMA)
al-Shaykhah, Hani M.& al-Beshbishi, Samar N.& al-Shazli, Atif M.& Hafiz, Adil Umar& Mursi, Tusun Ali. Kinetics of eosinophilia and IGE production in experimental murine toxocariasis. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 1, pp.53-64.
https://search.emarefa.net/detail/BIM-280141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 62-64
Record ID
BIM-280141