Is acquired total protein a deficiency associated with antiphospholipid antibodies in systemic lupus erythematosus?

Abstract EN

Hypothesis : protein S (PS) is a vitamin K dependent plasma protein, and it’s free from is required for protein C to be functional.

Ant phospholipid antibodies (apl) may cause functional PS deficiency by binding free PS.

In patients with SLE have increased incidence of apl, which have been associated with thrombotic events.

Objective : to determine the level of total protein S and its relation to (apl).

Methodology : 22 SLE patients diagnosed according to ACR revised criteria (Tan et al., 1982) and ten healthy subjects were included in this study.

Assays for protein S, IgG, apl were performed in patients and control groups.

Results : the protein S was lower in the patients than the control and the difference was highly significant.

There was a highly significant differences between the level of PS in patients with apl +ve compared with apl -ve patients (p < 0.01).

Conclusion : this study confirms an association between apl and PS deficiency.