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Differential therapeutic approach in patients with clinical stage of nonseminomatous germ cell testicular tumors Long-term experience
Joint Authors
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 10, Issue 3 (31 Jul. 2008), pp.163-168, 6 p.
Publisher
Publication Date
2008-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : surveillance after orchiectomy alone has become popular for the management of clinical stage nonseminomatous germ cell tumors of the testis (CS I NSGCTT).
Efforts to identify patients at high risk of relapse led to a search for prognostic factors of CS I NSGCTT.
The aim of this study was to analyses long-term experiences with different therapeutic approaches in CS I NSGCTT patients according to relapse risk factors.
Methods : from 2 / 1992 to 5 / 2008, a total of 352 CS I NSGCTT patients were included in the study and stratified into different risk-adapted therapeutic approaches (groups 1-3).
114 patients (group 1) with vascular invasion and majority of embryonic carcinoma component in the primary tumor were treated with 2 cycles of BEP chemotherapy.
Results : relapse was experienced in 2 patients (1.75 %).
Among 12 patients (group 2) with vascular invasion and majority of teratomatous elements in the primary tumor undergoing primary retroperitoneal lymph node dissection (RPLND), 10 were found to be in pathological stage I.
Relapse was observed in two patients (16.7 %).
One of whom died 29 months following orchiectomy.
Two patients (18.2 %) with pathological stage II received adjuvant chemotherapy and finally died.
226 patients (group 3) without vascular invasion were followed after orchiectomy.
Relapse was observed in 41 patients (18.1 %).
They were treated with BEP chemotherapy, which three died.
The overall survival rate of all the patients in group B1-3 was 98.3 %.
Conclusion : surveillance procedure is recommended only in patients without vascular invasion in the primary tumor.
American Psychological Association (APA)
Ondrus, D.& Ondrusova, M.. 2008. Differential therapeutic approach in patients with clinical stage of nonseminomatous germ cell testicular tumors Long-term experience. Iranian Red Crescent Medical Journal،Vol. 10, no. 3, pp.163-168.
https://search.emarefa.net/detail/BIM-28186
Modern Language Association (MLA)
Ondrus, D.& Ondrusova, M.. Differential therapeutic approach in patients with clinical stage of nonseminomatous germ cell testicular tumors Long-term experience. Iranian Red Crescent Medical Journal Vol. 10, no. 3 (Jul. 2008), pp.163-168.
https://search.emarefa.net/detail/BIM-28186
American Medical Association (AMA)
Ondrus, D.& Ondrusova, M.. Differential therapeutic approach in patients with clinical stage of nonseminomatous germ cell testicular tumors Long-term experience. Iranian Red Crescent Medical Journal. 2008. Vol. 10, no. 3, pp.163-168.
https://search.emarefa.net/detail/BIM-28186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 167-168
Record ID
BIM-28186