Formulation of alpha tocopherol acetate as a powder dosage form by adsorption

Abstract EN

Alpha-tocopherol acetate is one of the most important vitamin Ederivatives that were used as antioxidants.

Adsorbents like kaolin, magnesium carbonate, and microcrystalline cellulose were used successfully to incorporate oily alpha-tocopherol acetate into an acceptable powder dosage form.

The results revealed that microcrystalline cellulose as adsorbents gave the best results with 50 % loading capacity at time, 8 minutes before and after incubation period (3 months at 30C˚), while kaolin and magnesium carbonate have been shown a significant difference before and after incubation.

Addition of 1 % w / w magnesium carbonate to the kaolin enhanced the loading capacity by decreasing the time of adsorption from 20 to 6 minutes and 47 to 9 minutes before and after incubation respectively.

The study indicated that the best adsorbent to be used in case of oral vitamin E toxicity is microcrystalline cellulose while magnesium carbonate could be used in the formulation for their best adsorption effect.