Synthesis of histidine-amoxillin condensed drug polymer
Joint Authors
al-Salami, Firyal M. A.
al-Sharify, Abbas N. M.
Kazim, Khudayr J.
Source
Iraqi National Journal of Chemistry
Issue
Vol. 2012, Issue 45 (31 Mar. 2012), pp.126-134, 9 p.
Publisher
University of Babylon College of Sciences
Publication Date
2012-03-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract AR
حضر البوليمر الدوائي من تكاثف الهستدين كلوريد الحامض مع الاموكسيلين كلوريد الحامض بنسبة مولية 1:1, و يكون ملائم للتحلل و الامتصاص و مسيطر علية لمدة أطول باستخدام بوليمر حامل للدواء.
قيست الخواص الفيزيائية و قيست اللزوجة الجوهرية باستخدام أوستولد فسكوميتر، و درس سرعة التحرر الدوائي بدوال حامضية مختلفة و بدرجة 37 م.
البوليمر المتكاثف شخص بمطياف الأشعة فوق البنفسجية و الأشعة تحت الحمراء و طيف الرنين النووي المغناطيسي.
البوليمر الدوائي المحضر أقل سمية عند تحلله.
Abstract EN
A novel drug polymer as a peptid-biopolymer was prepared from histidineacidchloride with amoxillinacidchloride, the condensed polymer was prepared with molar ratio 1 : 1, this biocompatible, biodegradable, reabsorb able condensed polymers with controlled lifetimes, which can be used as drug carrier polymer.
The physical properties were measured and the intrinsic viscosity was measured using Ostwald viscometer, The controlled release rates were studied in different pH values at 37 0C.
The condensed polymer was characterized by UV-vis.
FTIR and 1H-NMR spectroscopy, This biomaterial polymer can be used as non-toxic substance.
When it undergo hydrolytic degradation.
American Psychological Association (APA)
al-Salami, Firyal M. A.& al-Sharify, Abbas N. M.& Kazim, Khudayr J.. 2012. Synthesis of histidine-amoxillin condensed drug polymer. Iraqi National Journal of Chemistry،Vol. 2012, no. 45, pp.126-134.
https://search.emarefa.net/detail/BIM-303976
Modern Language Association (MLA)
al-Salami, Firyal M. A.…[et al.]. Synthesis of histidine-amoxillin condensed drug polymer. Iraqi National Journal of Chemistry No. 45 (2012), pp.126-134.
https://search.emarefa.net/detail/BIM-303976
American Medical Association (AMA)
al-Salami, Firyal M. A.& al-Sharify, Abbas N. M.& Kazim, Khudayr J.. Synthesis of histidine-amoxillin condensed drug polymer. Iraqi National Journal of Chemistry. 2012. Vol. 2012, no. 45, pp.126-134.
https://search.emarefa.net/detail/BIM-303976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 134
Record ID
BIM-303976
