Evaluate of malondialdehyde level and antioxidant systems in asthma patients

Abstract EN

Background : asthma is a chronic airway inflammation which involves the interplay of different types of inflammatory cells and cytokines in the airway, it is characterized by recurrent cough and wheeze, recent small scale studies have demonstrated that asthma severity may be associated with both airway and systemic inflammation.

Purpose : it is determined that disturbance of oxidant-antioxidant balance in inflammatory disease especially in asthma.

Materials and Methods: Malondialdehyde, super oxide dismutase, catalase and glutathione (GSH) were conducted on 25patients( males) aged 28-45 years compared with 20 males sex and age matched as a healthy control.

Results : serum malondialdehyde level was shown a significantly increased in asthma patients compared with healthy control, but super oxide dismutase (SOD), catalase (CAT) & glutathione (GSH) were significantly decreased for asthma patients compared with healthy control.