Physiological and anatomical studies on the effect of salvia officinalis on the blood and pancreas in normal and streptozotocin-induced diabetic rats
Other Title(s)
دراسة تشريحية و فسيولوجية لتأثير نبات الميرمية على الدم و البنكرياس على الجرذان السليمة و الجرذان المصابة بمرض البول السكري المستحدث
Dissertant
Thesis advisor
al-Tamimi, Husam Jamal
al-Shakanbah, Jumah Muti
Comitee Members
Sad al-Din, Raja Abd al-Razzaq
Atruz, Umar Muhammad Falih
University
Mutah University
Faculty
Faculty of Science
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2009
English Abstract
The leaves of Salvia officinalis (Sg) are known to have a wide range of biological effects including antibacterial, fungistatic and virustatic, and has long been used within the domain of alternative medicine in human therapy.
Three experiments were carried out using a total of 108 male adult albino rats to study different physiological and anatomical parameters on the effect of Sg on selected blood biochemical parameters and pancreas in normal and sreptozotocin (St) induced-diabetic rats.
In the first experiment, Sg (methanolic extract) was administered intraperitoneally in (12) rats, for a total of 35 days in St-treated and/or untreated rats.
A significant decrease in glucose, triglyceride, cholesterol and uric acid, while no significant change in albumin, ALAT, ASAT, creatinine, total protein, alkaline phosphatase, urea, calcium, sodium, potassium, billirubin, and creatinine kinase in treated diabetic induced rats compared with untreated diabetic rats.
In the second experiment, Sg (methanolic extract) was administered in drinking water in (12) rats, for a total of 32 days in St-treated and/or untreated rats.
There was a significant decrease in glucose and cholesterol levels, while there was no significant change in other parameters in treated diabetic rats compared with untreated diabetic rats.
In the third experiment, Sg (water extract) was administered in drinking water in 30 rats, for a total of 30 days in St-treated and/or untreated rats.
Treatment with Sg for 15 days showed a significant decrease in glucose, creatinine and albumin level, in treated diabetic rats compared with untreated diabetic rats.
Treatment with Sg for 30 days showed a significant decrease in glucose, creatinine, urea levels, while there was a significant increase in albumin and calcium values in treated diabetic rats compared with untreated diabetic rats.
Histopathological study showed a total increase in the number of langerhans islets in treated diabetic rats.
Main Subjects
Topics
No. of Pages
93
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter one : Theoretical background.
Chapter two : Literature review.
Chapter three : Materials and methods.
Chapter four : Results.
Chapter five : Discussion, conclusion and recommendations.
References.
American Psychological Association (APA)
al-Uran, Tasnim Mufaddi. (2009). Physiological and anatomical studies on the effect of salvia officinalis on the blood and pancreas in normal and streptozotocin-induced diabetic rats. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-304959
Modern Language Association (MLA)
al-Uran, Tasnim Mufaddi. Physiological and anatomical studies on the effect of salvia officinalis on the blood and pancreas in normal and streptozotocin-induced diabetic rats. (Master's theses Theses and Dissertations Master). Mutah University. (2009).
https://search.emarefa.net/detail/BIM-304959
American Medical Association (AMA)
al-Uran, Tasnim Mufaddi. (2009). Physiological and anatomical studies on the effect of salvia officinalis on the blood and pancreas in normal and streptozotocin-induced diabetic rats. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-304959
Language
English
Data Type
Arab Theses
Record ID
BIM-304959
