Virologic response at week 8 of combined treatment as a predictor of sustained virologic response in non rapid virologic response, chronic HCV genotype 4 infected patients
Joint Authors
al-Sawwaf, Riham
Munis, Ali
Munis, Ahmad Ali
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 13, Issue 3 (31 Dec. 2012), pp.331-335, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Optimization of interferon-based treatment regimens remains an important goal as regulated interferon is likely to remain the backbone of chronic HCV treatment in the foreseeable future.
The objective of the current study was to evaluate virological response at week 8 of combined treatment as a predictor of sustained virology response (SVR) in non-rapid virology response (RVR), chronic HCV genotype 4 infected patients.
A total of 38 patients with chronic HCV genotype 4 infection were enrolled in the study.
All patients received a combination of pegylated interferon a-2a plus ribavirin.
Virological response at week 8 of combined treatment was evaluated as a predictor of SVR.
Week 8 response was more sensitive but less specific than RVR in predicting SVR, in non RVR patients (24 patients), week 8 response had a sensitivity of 45.5 % and a specificity of 76.9 % for predicting SVR.
In conclusion : in non RVR patients, measurement of HCV RNA at week 8 is an optimal time to identify those who are not going to benefit from pegylated interferon and ribavirin combination therapy.
American Psychological Association (APA)
Munis, Ali& Munis, Ahmad Ali& al-Sawwaf, Riham. 2012. Virologic response at week 8 of combined treatment as a predictor of sustained virologic response in non rapid virologic response, chronic HCV genotype 4 infected patients. The Egyptian Journal of Medical Human Genetics،Vol. 13, no. 3, pp.331-335.
https://search.emarefa.net/detail/BIM-313049
Modern Language Association (MLA)
Munis, Ali…[et al.]. Virologic response at week 8 of combined treatment as a predictor of sustained virologic response in non rapid virologic response, chronic HCV genotype 4 infected patients. The Egyptian Journal of Medical Human Genetics Vol. 13, no. 3 (2012), pp.331-335.
https://search.emarefa.net/detail/BIM-313049
American Medical Association (AMA)
Munis, Ali& Munis, Ahmad Ali& al-Sawwaf, Riham. Virologic response at week 8 of combined treatment as a predictor of sustained virologic response in non rapid virologic response, chronic HCV genotype 4 infected patients. The Egyptian Journal of Medical Human Genetics. 2012. Vol. 13, no. 3, pp.331-335.
https://search.emarefa.net/detail/BIM-313049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 335
Record ID
BIM-313049