Effect of newly prepared compound in induced diabetic and hyperlipidemic albino rats
Dissertant
Thesis advisor
al-Hayyari, Yusuf M.
Mansi, Kamal M.
Comitee Members
Abu Rajai, Talal
Abu Zaytun, Ahmad
Abu al-Basal, Maryam
University
Al albayt University
Faculty
Faculty of Sciences
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2012
English Abstract
The present study aims to investigate the hypolipidemic effect of N-[4-benzoylphcny] indole-2-carboxamide on three animal models of experimental rats.
The first model was hyperlipidemic diet rats induced by diet.
The rats were given fatty diet, which was prepared by mixing 0.5 % cholesterol, 1 / 4 % cholic acid fat, and 2 % corn oil with standard powdered animal's food for two months.
In the second hyperlipidemic triton rat model, the hyperlipidemia was induced by injection (i.p) with Triton WR-1339 (250 mg / kg body weight).
Both models have shown significant increase in serum cholesterol, LDL, triglyceride, and decrease HDL levels, compared to control group upon diet or triton treatment.
In the third model, the diabetic rats were induced by injection (i.p) with alloxan (150 mg / kg body weight).
The rats were shown significant (P < 0.05) increase in the glucose level in alloxan treated rats compared to control group.
After treated with N-[4-benzoylphenyl]-l-indole-2-carboxamide (15mg / kg body weight), the hyperlipidemic models showed significant decrease (p < 0.05) in serum cholesterol, LDL, triglyceride, and increase HDL levels compared to hyperlipidemic groups.
However, the effect of N-[4-benzoylphenyl]- indole-2-carboxamide (15mg / kg body weight) was not significant (p < 0.05) in diabetic group rats induced by alloxan.
In conclusion, the new compound proved to be potential antihyperlipidimic agent.
Main Subjects
Topics
No. of Pages
51
Table of Contents
Table of contents.
Abstract.
Chapter One : introduction.
Chapter Two : materials and methods.
Chapter Three : results.
Chapter Four : discussion.
References.
American Psychological Association (APA)
al-Jamal, Umaymah Ghalib. (2012). Effect of newly prepared compound in induced diabetic and hyperlipidemic albino rats. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321488
Modern Language Association (MLA)
al-Jamal, Umaymah Ghalib. Effect of newly prepared compound in induced diabetic and hyperlipidemic albino rats. (Master's theses Theses and Dissertations Master). Al albayt University. (2012).
https://search.emarefa.net/detail/BIM-321488
American Medical Association (AMA)
al-Jamal, Umaymah Ghalib. (2012). Effect of newly prepared compound in induced diabetic and hyperlipidemic albino rats. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-321488
Language
English
Data Type
Arab Theses
Record ID
BIM-321488
