Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses
Other Title(s)
دراسة التفاعل الحاد و المزمن بين الأسبرين و الكابتوبريل بمختلف الجرع في الجرذان
Joint Authors
Hadi, Najah Raiesh
Mahd, Sadiyah Salih
Abbas, Durayd Abd al-Hadi
Source
Issue
Vol. 12, Issue 1 (30 Jun. 2009), pp.268-276, 9 p.
Publisher
University of Kufa Faculty of Medicine
Publication Date
2009-06-30
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
The present studies were conducted to determine acute and chronic toxicity of aspirin and captopril given alone or in combination in seventy rats were used, 21 rats for acute toxicity (LD50) of aspirin, captopril and their combination in single dose, while the other forty nine rats were used to determine chronic toxicity effect which were divided into 4 groups, the control group (7 rats) received distilled water, the other three treatment groups each group (14) rats were divided into two subgroups T1 and T2 according to the following oral daily dosing regiment ( aspirin subgroup 2 and 4 Mg / kg , captopril, 6 and 12 mg/kg and aspirin + captopril ( 2 + 6 mg / kg and 4 + 12 mg / kg) respectively. LD50 was measured for all groups after their chronic treatment to determine chronic index. The results of acute toxicity (LD50) were, for captopril 4.3705 g / kg, aspirin 5.3705 G / kg and their combination (captopril 2.1295 g / kg + 2.6295 g / kg aspirin), respectively that reduced after chronic drug exposure to 3.1315 g / kg captopril, 3.1295g / kg aspirin and captopril 1.6315 g / kg + 2.1315 g / kg aspirin. Isobolographic analysis of two drug LD50 showed that there were an additive effect after acute toxic exposure and antagonism after chronic one No accumulation was reported between the two drugs and their combination after 3 month daily treatment according to the results of chronic index of all treated groups. This study indicate that LD50 isobolographic analysis for captopril and aspirin showed an additive effect after acute exposure and antagonism after chronic administration and no accumulation effect for both drugs.
American Psychological Association (APA)
Abbas, Durayd Abd al-Hadi& Hadi, Najah Raiesh& Mahd, Sadiyah Salih. 2009. Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses. Kufa Medical Journal،Vol. 12, no. 1, pp.268-276.
https://search.emarefa.net/detail/BIM-326776
Modern Language Association (MLA)
Hadi, Najah Raiesh…[et al.]. Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses. Kufa Medical Journal Vol. 12, no. 1 (2009), pp.268-276.
https://search.emarefa.net/detail/BIM-326776
American Medical Association (AMA)
Abbas, Durayd Abd al-Hadi& Hadi, Najah Raiesh& Mahd, Sadiyah Salih. Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses. Kufa Medical Journal. 2009. Vol. 12, no. 1, pp.268-276.
https://search.emarefa.net/detail/BIM-326776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 275-276
Record ID
BIM-326776