Prevalence of YMDD variants leading to lamivudine resistance among chronic HBV patients in Gaza Strip-Palestine running title : lamivudine resistance in Gaza Strip-Palestine
Joint Authors
al-Manaimah, Abd al-Rauf A.
Ayish, Basim Muhammad
Abu Zuhri, Iman O.
Source
IUG Journal of Natural Studies
Issue
Vol. 21, Issue 2 (30 Jun. 2013), pp.95-102, 8 p.
Publisher
The Islamic University-Gaza Deanship of Research and Graduate Affairs
Publication Date
2013-06-30
Country of Publication
Palestine (Gaza Strip)
No. of Pages
8
Main Subjects
Topics
Abstract EN
Several areas worldwide.
The prevalence of YMDD variants (YIDD and YVDD) and some risk factors leading to lamivudine resistance were investigated among chronic HBV patients in Gaza strip.
Methodology Fifty four patients with viral load above 4500 IU / ml from two governmental hospitals were tested for Lamivudine resistance from October, 2008 to July, 2011.
Real Time PCR determination for viral load and Liver function tests were also carried out.
Results : The prevalence of YMDD variants was determined and divided into five groups : YMDD (32.6 %), YMDD / YIDD in (41.3 %), YIDD alone (13 %), YIDD / YVDD(2.2 %),YMDD / YIDD / YVDD (10.9 %).
A statistically significant correlation was found between viral load and the preceding five groups (p = 0.028).
The only significant risk factor for lamivudine resistance was lamivudine intake duration (p = 0.049).
Conclusion : The prevalence of YMDD variants due to lamivudine resistance among Gaza HBV patients was found to be high, therefore, re-evaluation of management protocols and policies for HBV therapy should be considered
American Psychological Association (APA)
al-Manaimah, Abd al-Rauf A.& Ayish, Basim Muhammad& Abu Zuhri, Iman O.. 2013. Prevalence of YMDD variants leading to lamivudine resistance among chronic HBV patients in Gaza Strip-Palestine running title : lamivudine resistance in Gaza Strip-Palestine. IUG Journal of Natural Studies،Vol. 21, no. 2, pp.95-102.
https://search.emarefa.net/detail/BIM-328251
Modern Language Association (MLA)
al-Manaimah, Abd al-Rauf A.…[et al.]. Prevalence of YMDD variants leading to lamivudine resistance among chronic HBV patients in Gaza Strip-Palestine running title : lamivudine resistance in Gaza Strip-Palestine. IUG Journal of Natural Studies Vol. 21, no. 2 (2013), pp.95-102.
https://search.emarefa.net/detail/BIM-328251
American Medical Association (AMA)
al-Manaimah, Abd al-Rauf A.& Ayish, Basim Muhammad& Abu Zuhri, Iman O.. Prevalence of YMDD variants leading to lamivudine resistance among chronic HBV patients in Gaza Strip-Palestine running title : lamivudine resistance in Gaza Strip-Palestine. IUG Journal of Natural Studies. 2013. Vol. 21, no. 2, pp.95-102.
https://search.emarefa.net/detail/BIM-328251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 101-102
Record ID
BIM-328251