Idiopathic autoimmune thrombocytopenic purpura (ITP) in adult ; review of 50 cases admitted to Baghdad teaching hospital
Joint Authors
Ulwan, Ala Fadil
al-Uqbi, Adil S.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 52, Issue 2 (30 Jun. 2010), pp.167-171, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2010-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Idiopathic autoimmune thrombocytopenia purpura (ITP) is an isolated thrombocytopenia in a patient with no clinically apparent associated conditions or factors that can cause thrombocytopenia.
The syndrome of ITP is caused by platelet-specific auto-antibodies that bind to autologous platelets.
The diagnosis of ITP is usually a diagnosis of exclusion based on a demonstration of peripheral thrombocytopenia.
Steroids are the conventional first-line therapy for adult ITP.
Most patients demonstrate a response to steroids within 2 to 4 weeks, but a late response is possible. Patients and Methods : A prospective study on 50 patients with diagnosis consistent with ITP, initially treated by steroid, patients who were non responders to steroids or relapsed following its withdrawal offered splenectomy Results : Ten patients (20 %) had permanent satisfactory remission following steroid therapy, while other 40 patients (80 %) were either non responders (20 patients, 40 %) or relapsed (20 patients, 40 %).
Twenty patients (40 %) underwent splenectomy, all of them initially responded, after 3-6 months, 17 patients of them (85 %) were still in complete remission, while 3 patients (15 %) were refractory ITP and required further treatment. Conclusion : Steroid therapy is less effective in achieving satisfactory remission in adult patient with ITP ; on the other hand, splenectomy had more sustained response after steroid failure.
American Psychological Association (APA)
al-Uqbi, Adil S.& Ulwan, Ala Fadil. 2010. Idiopathic autoimmune thrombocytopenic purpura (ITP) in adult ; review of 50 cases admitted to Baghdad teaching hospital. Journal of the Faculty of Medicine Baghdad،Vol. 52, no. 2, pp.167-171.
https://search.emarefa.net/detail/BIM-335819
Modern Language Association (MLA)
al-Uqbi, Adil S.& Ulwan, Ala Fadil. Idiopathic autoimmune thrombocytopenic purpura (ITP) in adult ; review of 50 cases admitted to Baghdad teaching hospital. Journal of the Faculty of Medicine Baghdad Vol. 52, no. 2 (2010), pp.167-171.
https://search.emarefa.net/detail/BIM-335819
American Medical Association (AMA)
al-Uqbi, Adil S.& Ulwan, Ala Fadil. Idiopathic autoimmune thrombocytopenic purpura (ITP) in adult ; review of 50 cases admitted to Baghdad teaching hospital. Journal of the Faculty of Medicine Baghdad. 2010. Vol. 52, no. 2, pp.167-171.
https://search.emarefa.net/detail/BIM-335819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 170-171
Record ID
BIM-335819