Homestasis model assessment-adiponectin ratio and adiponectin-resistin index as markers of insulin resistance in type 2 diabetes mellitus
Joint Authors
Hamid, Ikhlas Khalid
Rashid, Nada F.
Ubayd, Bayda A.
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 55, Issue 2 (30 Jun. 2013), pp.175-178, 4 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2013-06-30
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background : insulin resistance (IR) is an important clinical and biochemical determinant of diabetes and many other clinical states.
The gold standard method for IR estimation is the hyperinsulinemic euglycaemic glucose clamp.
Adiponectin and resistin are adipocytes derived hormones that play important role in the regulation of glucose, fat metabolism and insulin resistance.
Objective : this study aimed to assess the validity of Homestasis Model Assessment-Adiponectin ratio and Adiponectin–Resistin index as markers of insulin resistance in type 2 diabetic mellitus (T2DM) patients.
Design : Ninety (T2DM) overweight male subjects were enrolled in this cross sectional study, detailed history, physical examination and anthropometric measures including BMI, waist, and hip circumference were done to all the participants.
Fasting serum samples were obtained and used for the measurement of serum glucose, serum triglyceride, high density lipoprotein(HDL), very low density lipoprotein(VLDL), HbA1c, also serum insulin, adiponectin, resistin were measured and HOMA-IR, HOMA-AD and AR-index were calculated.SPSS-17 was used to analyze the data.
Results : AR-index correlates significantly with FSG, Fasting Insulin and HOMA-IR (r = 0.534.p = 0.005), (r = 0.545, p = 0.005), (r = 0.506, p = 0.008) respectively HOMA-AD correlates with FSG (R = 0.551, P = 0.001), insulin (P = 0.956,p = 0.000), HOMA-IR (r = 0.952, p = 0.000).
AUC for AR-index (0.800) and for HOMA-AD (0.905).
Conclusions : HOMA-AD and AR-index are reliable and valid measures for the assessment of insulin resistance in type 2 diabetic patients.
American Psychological Association (APA)
Hamid, Ikhlas Khalid& Rashid, Nada F.& Ubayd, Bayda A.. 2013. Homestasis model assessment-adiponectin ratio and adiponectin-resistin index as markers of insulin resistance in type 2 diabetes mellitus. Journal of the Faculty of Medicine Baghdad،Vol. 55, no. 2, pp.175-178.
https://search.emarefa.net/detail/BIM-336315
Modern Language Association (MLA)
Rashid, Nada F.…[et al.]. Homestasis model assessment-adiponectin ratio and adiponectin-resistin index as markers of insulin resistance in type 2 diabetes mellitus. Journal of the Faculty of Medicine Baghdad Vol. 55, no. 2 (2013), pp.175-178.
https://search.emarefa.net/detail/BIM-336315
American Medical Association (AMA)
Hamid, Ikhlas Khalid& Rashid, Nada F.& Ubayd, Bayda A.. Homestasis model assessment-adiponectin ratio and adiponectin-resistin index as markers of insulin resistance in type 2 diabetes mellitus. Journal of the Faculty of Medicine Baghdad. 2013. Vol. 55, no. 2, pp.175-178.
https://search.emarefa.net/detail/BIM-336315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 177-178
Record ID
BIM-336315