Breast cancer laterality among Egyptian patients and its association with treatments and survival
Joint Authors
Ramadan, Muhammad
al-Mashad, Nahhal
Diya, Amirah
Masad, Ihab
Fakhr, Ibrahim
Zayn al-Din, Ahmad A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 25, Issue 4 (31 Dec. 2013), pp.199-207, 9 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Background and aim : breast cancers (BCs) involve the left side (LS) more than the right side (RS).
Among the Egyptians, neither BC laterality nor its association with demographic factors, tumor locations, treatments and outcomes were previously reported.
Patients and methods: Laterality was analyzed among 5459 BCs from the Gharbiah populationbased cancer registry covering > 5 % of the Egyptian population.
Cox proportional model was used to assess the independent effect of stage, ER, and laterality on overall survival (OS).
Results : in Egypt, BCs involve LS more than RS with LS-to-RS ratio (LRR) of 1.16.
LS predominance was evident among men and women and both younger (< 45 years) and older patients.
HER2 over-expression and ductal cancers were significantly more in RSBCs while lobular cancers were significantly more in LSBCs.
There were no significant differences in localization within the breast between LSBCs and RSBCs (p = 0.51).
LS predominance was noticed across all subgroups except in patients with HER2 positive tumors (LRR = 0.63 ; p = 0.02).
OS was significantly better in stage II and ER positive tumors than stage III and ER negative tumors.
Despite OS of LSBCs being generally lower than RSBCs, this was not statistically significant.
The significant impact of stage on OS was lost in LSBCs.
Conclusions : Among Egyptian patients, the left breast is at greater risk of cancer than the right one.
Despite right-sided tumors seemed more aggressive, Left-sided ones tend to confer worse survival than right-sided tumors.
American Psychological Association (APA)
Zayn al-Din, Ahmad A.& Ramadan, Muhammad& al-Mashad, Nahhal& Fakhr, Ibrahim& Diya, Amirah& Masad, Ihab. 2013. Breast cancer laterality among Egyptian patients and its association with treatments and survival. Journal of the Egyptian National Cancer Institute،Vol. 25, no. 4, pp.199-207.
https://search.emarefa.net/detail/BIM-347898
Modern Language Association (MLA)
Zayn al-Din, Ahmad A.…[et al.]. Breast cancer laterality among Egyptian patients and its association with treatments and survival. Journal of the Egyptian National Cancer Institute Vol. 25, no. 4 (Dec. 2013), pp.199-207.
https://search.emarefa.net/detail/BIM-347898
American Medical Association (AMA)
Zayn al-Din, Ahmad A.& Ramadan, Muhammad& al-Mashad, Nahhal& Fakhr, Ibrahim& Diya, Amirah& Masad, Ihab. Breast cancer laterality among Egyptian patients and its association with treatments and survival. Journal of the Egyptian National Cancer Institute. 2013. Vol. 25, no. 4, pp.199-207.
https://search.emarefa.net/detail/BIM-347898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 206-207
Record ID
BIM-347898