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Synthesis, characterization, antimicrobial and diuretic study of Mg (II), Mn (II), Fe (II) and VO (II) complexes of chemotherapeutic importance
Joint Authors
Iqbal, Sayyid Aftab
Ghosh, Suparna
Malik, Suman
Jain, Bharti
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 2 (30 Apr. 2012), pp.137-142, 6 p.
Publisher
Publication Date
2012-04-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The synthesis, characterization and diuretic activity of four new biologically active complexes of Mg(II) and VO(II) with bidentate Schiff base ligand acetazolamide–salicylaldimine (L) obtained from the inserted condensation of 5-acetamido-1,3,4-thiadiazole-2-sulphonamide (acetazolamide) with salicylaldehyde in a 1:1 molar ratio have been reported.
Using this bidentate ligand complexes of Mg(II), Mn(II), Fe(II) and VO(II) with general formula ML2 have been synthesized.
The synthesized complexes were characterized by several techniques using elemental analysis, FTIR, electronic spectra, TGA, mass, particle size analysis and molar conductance measurements.
The elemental analysis data suggest the stoichiometry to be 1:2 [M:L].
The molar conductance measurements suggest non-electrolytic nature of the complexes.
Infrared spectral data agreed with the coordination to the central metal ion through deprotonated phenolic oxygen and azomethine nitrogen atoms.
On the basis of spectral studies, octahedral geometry is suggested for Mg(II), Mn(II), Fe(II) and square pyramidal geometry is suggested for VO(II) complexes.
The pure drug, synthesized ligand and metal(II) complexes were screened for their antimicrobial activities against Eschericia coli, Bacillus subtilis, Aspergillus niger and Aspergillus flavous.
The results show that the metal complexes were more active than the ligand and pure drug against these microbial species as expected.
The ligand and its Mg(II) complexes was screened for their diuretic activity also.
American Psychological Association (APA)
Ghosh, Suparna& Malik, Suman& Jain, Bharti& Iqbal, Sayyid Aftab. 2012. Synthesis, characterization, antimicrobial and diuretic study of Mg (II), Mn (II), Fe (II) and VO (II) complexes of chemotherapeutic importance. Journal of Saudi Chemical Society،Vol. 16, no. 2, pp.137-142.
https://search.emarefa.net/detail/BIM-351673
Modern Language Association (MLA)
Ghosh, Suparna…[et al.]. Synthesis, characterization, antimicrobial and diuretic study of Mg (II), Mn (II), Fe (II) and VO (II) complexes of chemotherapeutic importance. Journal of Saudi Chemical Society Vol. 16, no. 2 (Apr. 2012), pp.137-142.
https://search.emarefa.net/detail/BIM-351673
American Medical Association (AMA)
Ghosh, Suparna& Malik, Suman& Jain, Bharti& Iqbal, Sayyid Aftab. Synthesis, characterization, antimicrobial and diuretic study of Mg (II), Mn (II), Fe (II) and VO (II) complexes of chemotherapeutic importance. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 2, pp.137-142.
https://search.emarefa.net/detail/BIM-351673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 142-143
Record ID
BIM-351673