In vitro antioxidant properties of new thiazole derivatives
Joint Authors
Jaishri, V.
Ramdas, N.
Sachin, J.
Ramesh, B.
Source
Journal of Saudi Chemical Society
Issue
Vol. 16, Issue 4 (31 Oct. 2012), pp.371-376, 6 p.
Publisher
Publication Date
2012-10-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
A series of novel N2-[2-chloro-4 (3, 4, 5-trimethoxy phenyl azetidin-1-yl]-N4-(substituted aryl)-1, 3-thiazole-2, 4-diamine (4a-g) were synthesized starting from 3, 4, 5-trimethoxy benzaldehyde thiosemicarbazone (1).
The compound (1) was obtained by condensing 3, 4, 5-trimethoxy benzaldehyde with thiosemicarbazide in methanol.
3,4,5-Trimethoxy benzaldehyde thiosemicarbazone (1) on treatment with chloracetyl chloride afforded 4-chloro-[2- (3, 4, 5-trimethoxy benzylidine) hydrazinyl]- 1, 3-thiazole (2).
Compound (2) was reacted with chloracetyl chloride and triethylamine to obtain the corresponding 4-chloro-N-[2-chloro-4 (3, 4, 5-trimethoxy phenyl) azetidin-1-yl]-1, 3-thiazole-2- amine (3).
Various substitutions on compound 3 with secondary amines yielded series of compounds (4a-g).
The newly synthesized compounds were characterized by IR, 1H NMR, elemental analysis and mass spectral studies.
All the compounds were screened for their in vitro antioxidant properties.
The IC50 values of compounds 3 and 4a–g revealed that some of the synthesized compounds were showing potent antioxidant activity.
American Psychological Association (APA)
Jaishri, V.& Ramdas, N.& Sachin, J.& Ramesh, B.. 2012. In vitro antioxidant properties of new thiazole derivatives. Journal of Saudi Chemical Society،Vol. 16, no. 4, pp.371-376.
https://search.emarefa.net/detail/BIM-351704
Modern Language Association (MLA)
Jaishri, V.…[et al.]. In vitro antioxidant properties of new thiazole derivatives. Journal of Saudi Chemical Society Vol. 16, no. 4 (Oct. 2012), pp.371-376.
https://search.emarefa.net/detail/BIM-351704
American Medical Association (AMA)
Jaishri, V.& Ramdas, N.& Sachin, J.& Ramesh, B.. In vitro antioxidant properties of new thiazole derivatives. Journal of Saudi Chemical Society. 2012. Vol. 16, no. 4, pp.371-376.
https://search.emarefa.net/detail/BIM-351704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 376
Record ID
BIM-351704