Expression of matrix metalloproteinase-2 in the extracellular matrix of osseointegrated and diseased implants

Abstract EN

Background : Recently with improvement of dental implantology science, osseointegrated implants show a considerable durability, however; failures are not completely avoidable.

Matrix metalloproteinase-2 (MMP-2) expression is disturbed in many pathological conditions such as peri-implantitis and periodontitis.

This study was carried out to investigate the tissue expression of MMP-2 in the extracellular matrix of osseointegrated and diseased implants.

Subjects and methods: Gingival biopsies were collected from six patients having osseointegrated or working implants and twenty with diseased or non osseointegrated implants and (6) controls having no implants.

In situ hybridization technique was used to analyze the changes in immunoreactivity of ECM-controlling MMP-2.

Results: The findings of the present study indicate that the expression of MMP2 was significantly elevated in failed implants versus healthy implants (P < 0.01).

In addition, MMP-2 was detected in peri-implant sites with ongoing bone loss, cavitations and inflammatory reaction.

Conclusion : The in situ hybridization technique, showed clear evidence that MMP-2, which is involved in the process of osseointegration and bone remodeling, increase greatly in the presence of bone destruction, cavitations, severe inflammation and fibrous tissue formation.

The data link titanium- induced bone remodeling to changes in expressionand distribution of MMP-2.