In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats
Joint Authors
Lakshman, K.
Kumar, B. S. Ashok
Nandeesh, R.
Kumar, P. A. Arun
Manoj, B.
Kumar, Vinod
Shekar, D. Sheshadri
Source
Saudi Journal of Biological Sciences
Issue
Vol. 18, Issue 1 (31 Mar. 2011), pp.1-5, 5 p.
Publisher
Publication Date
2011-03-31
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
Amaranthus spinosus Linn.
(Amaranthaceae), commonly known as ‘‘Mulluharivesoppu’’ in Kannada, is used in the Indian traditional system of medicine for the treatment of diabetes.
The present study deals with the scientific evaluation of alpha amylase and the antioxidant potential of methanol extract of A.
spinosus (MEAS).
The aim of this study was to investigate in vitro alphaamylase enzyme inhibition by CNPG3 (2-chloro-4-nitrophenol a-D-maltotrioside) and in vivo antioxidant potential of malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and total thiols (TT) in alloxan-induced diabetic rats of a methanolic extract of A.
spinosus.
Blood sugar was also determined in MEAS-treated alloxan-induced diabetic rats.
MEAS showed significant inhibition of alpha-amylase activity and IC50 46.02 lg / ml.
Oral administration of MEAS (200 and 400 mg / kg) for 15 days showed significant reduction in the elevated blood glucose, MDA and restores GSH, CAT and TT levels as compared with a diabetic control.
The present study provides evidence that the methanolic extract of A.
spinosus has potent alpha amylase, anti-diabetic and antioxidant activities.
American Psychological Association (APA)
Kumar, B. S. Ashok& Lakshman, K.& Nandeesh, R.& Kumar, P. A. Arun& Manoj, B.& Kumar, Vinod…[et al.]. 2011. In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats. Saudi Journal of Biological Sciences،Vol. 18, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-357559
Modern Language Association (MLA)
Kumar, B. S. Ashok…[et al.]. In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats. Saudi Journal of Biological Sciences Vol. 18, no. 1 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-357559
American Medical Association (AMA)
Kumar, B. S. Ashok& Lakshman, K.& Nandeesh, R.& Kumar, P. A. Arun& Manoj, B.& Kumar, Vinod…[et al.]. In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 1, pp.1-5.
https://search.emarefa.net/detail/BIM-357559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-357559