Amelioratory effects of vitamin E against biochemical toxicity induced by deltamethrin in male rats

Abstract EN

Deltamethrin (DLM) is a synthetic pyrethroid insecticide known for its wide toxic manifestations.

The present experiment pertains to the protective role of vitamin E (vit E) against biochemical toxicity following pesticide exposure during 30 days.

Materials and methods Male albino rats were divided into four groups of six each: Group I served as control rats (0 mg (vit E) and 0 mg DLM / kg body weight), Group II received deltamethrin (7.5mg / kg body weight).

Group III received vit E (100 mg / kg body weight).

Group IV received both deltamethrin (7.5mg / kg body weight) plus vit E (100mg / kg body weight).

Results Exposure of rats to DLM induced significant increase in the levels of hepatic markers enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) ; while acetylcholinesterase (AChE) was inhibited.

Significant decrease in catalase (CAT) and glutathione S-transferase (GST) enzyme activities were observed in treated rats.

Furthermore, renal markers such as urea and creatinine were increased in deltamethrin treated rats.

Additionally, serum cholesterol, triglycerides, low-density lipoprotein (LDL) and the level of high-density lipoprotein (HDL) were significantly increased and decreased, respectively.

Co-administration of vit E restored all the parameters cited above to near-normal values.

Conclusion our investigation showed that vit E acts as an effective antioxidant for DLM pesticide toxicity in reducing oxidative stress burden.