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Cytotoxicity and antioxidant activity of 5-(2, 4-dimethylbenzyl) pyrrolidin-2-one extracted rom marine Streptomyces VITSVK5 spp.
Joint Authors
Saurav, Kumar
Kannabiran, Krishnan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 19, Issue 1 (31 Mar. 2012), pp.81-86, 6 p.
Publisher
Publication Date
2012-03-31
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
The aim of the present study was to evaluate the cytotoxicity and antioxidant activity of 5-(2,4-dimethylbenzyl)pyrrolidin-2-one (DMBPO) extracted from marine Streptomyces VITSVK5 spp.
The strain was isolated from sediment samples collected at the Marakkanam coast of Bay of Bengal, India.
Systematic screening of isolates for anti-Aspergillus activity resulted in the identification of Streptomyces species designated as Streptomyces VITSVK5 spp.
Bioactivity guided extraction and purification yielded a compound 5-(2,4-dimethylbenzyl)pyrrolidin-2-one (DMBPO) and was tested for cytotoxicity and antioxidant activity.
The structure of the extracted compound was established by spectroscopic studies and identified as 5-(2,4-dimethylbenzyl)pyrrolidin- 2-one (DMBPO).
DMBPO exhibited cytotoxic activity on HEP 2 and Hep G2 cell lines with the IC50 value of 2.8 lg/ml and 8.3 lg/ml, respectively, as compared to Vero cell line (22.6).
DMBPO showed the hemolytic EC50 value of 288 lg/ml on human erythrocytes.
DMBPO treatment showed fewer (31.7%) aberrations, gaps and chromatid breaks as compared to untreated controls (27.8%) of human chromosomes.
DMBPO also exhibited significant (44.13% at 5 lg/ml DMBPO) DPPH radical scavenging activity and total antioxidant activity (50.10% at 5 lg/ml DMBPO).
The results of this study showed that DMBPO is cytotoxic to cancer cells and possesses antioxidant property
American Psychological Association (APA)
Saurav, Kumar& Kannabiran, Krishnan. 2012. Cytotoxicity and antioxidant activity of 5-(2, 4-dimethylbenzyl) pyrrolidin-2-one extracted rom marine Streptomyces VITSVK5 spp.. Saudi Journal of Biological Sciences،Vol. 19, no. 1, pp.81-86.
https://search.emarefa.net/detail/BIM-360011
Modern Language Association (MLA)
Saurav, Kumar& Kannabiran, Krishnan. Cytotoxicity and antioxidant activity of 5-(2, 4-dimethylbenzyl) pyrrolidin-2-one extracted rom marine Streptomyces VITSVK5 spp.. Saudi Journal of Biological Sciences Vol. 19, no. 1 (2012), pp.81-86.
https://search.emarefa.net/detail/BIM-360011
American Medical Association (AMA)
Saurav, Kumar& Kannabiran, Krishnan. Cytotoxicity and antioxidant activity of 5-(2, 4-dimethylbenzyl) pyrrolidin-2-one extracted rom marine Streptomyces VITSVK5 spp.. Saudi Journal of Biological Sciences. 2012. Vol. 19, no. 1, pp.81-86.
https://search.emarefa.net/detail/BIM-360011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 86
Record ID
BIM-360011