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Interleukin 10 gene promoter polymorphism and risk of diffuse large B cell lymphoma (DLBCL)
Joint Authors
Talat, Roba M.
Abd al-Aziz, Amal M.
al-Maadawi, Iman A.
Abd Bari, Nasir
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 1 (31 Jan. 2014), pp.7-13, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Purpose : Given the importance of understanding the genetic variations involved in the pathogenesis of non-Hodgkin’s lymphoma (NHL), this work was designed to study the impact of IL-10 ( 1082 G / A ; rs1800896 and 819 C / T ; rs1800871) gene promoter polymorphism on susceptibility of Egyptians to diffuse large B cell lymphoma (DLBCL) ; the major type of NHL.
To the best of our knowledge, this study is the first one that examines IL-10 promoter polymorphism in DLBCL in Egyptians.
Methods : Genotyping polymorphism is performed using sequence-specific primers polymerase chain reaction (SSP-PCR) in 100 Egyptian DLBCL patients and 119 normal controls.
Circulating plasma levels of IL-10 were measured using Enzyme-linked immunosorbent assay (ELISA).
Results : Insignificant change in IL-10 ( 1082 and 819) genotypes was recorded.
Although A allele is slightly decreased in DLBCL patients, it did not reach statistical significance.
GT haplotype was significantly elevated (P < 0.05) in NHL patients.
A significant linkage disequilibrium between the 1082 and 819 SNPs with D0 = 0.596 and r2 = 0.1032 (P < 0.001) was demonstrated.
Significantly increased plasma IL-10 (P < 0.01) was found which is positively correlated (r = 0.307 ; P < 0.01) with the disease.
American Psychological Association (APA)
Talat, Roba M.& Abd al-Aziz, Amal M.& al-Maadawi, Iman A.& Abd Bari, Nasir. 2014. Interleukin 10 gene promoter polymorphism and risk of diffuse large B cell lymphoma (DLBCL). The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 1, pp.7-13.
https://search.emarefa.net/detail/BIM-360498
Modern Language Association (MLA)
Talat, Roba M.…[et al.]. Interleukin 10 gene promoter polymorphism and risk of diffuse large B cell lymphoma (DLBCL). The Egyptian Journal of Medical Human Genetics Vol. 15, no. 1 (Jan. 2014), pp.7-13.
https://search.emarefa.net/detail/BIM-360498
American Medical Association (AMA)
Talat, Roba M.& Abd al-Aziz, Amal M.& al-Maadawi, Iman A.& Abd Bari, Nasir. Interleukin 10 gene promoter polymorphism and risk of diffuse large B cell lymphoma (DLBCL). The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 1, pp.7-13.
https://search.emarefa.net/detail/BIM-360498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-13
Record ID
BIM-360498