Synthesis and reducing power assay of methyl semicarbazone derivatives
Joint Authors
Singhal, Manmohan
Paul, Arindam
Singh, Hemendra P.
Source
Journal of Saudi Chemical Society
Issue
Vol. 18, Issue 2 (30 Apr. 2014), pp.121-127, 7 p.
Publisher
Publication Date
2014-04-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
In the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ by pharmacophore hybridization approach of drug design.
A series of novel chalconesemicarbazones was synthesized and evaluated for their antioxidant activity by reducing power assay.
Most of the compounds were found to be potent antioxidants.
Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions.
Based on the results of reducing power assay 1-[1-(2, 4-dihydroxyphenyl)-3-(2- hydroxyphenyl)allylidene]-4-(4-methylphenyl)semicarbazide (compound 18) and 1-[1-(2, 5-dihydroxyphenyl)- 3-(6-hydroxyphenyl) allylidene]-4-(4-methylphenyl) semicarbazide (compound 21) were the most active lead compounds.
It was found that methoxy and hydroxyl substituted chalconesemicarbazones exhibited potent reducing power and unsubstituted compound showed less reducing potential.
American Psychological Association (APA)
Singhal, Manmohan& Paul, Arindam& Singh, Hemendra P.. 2014. Synthesis and reducing power assay of methyl semicarbazone derivatives. Journal of Saudi Chemical Society،Vol. 18, no. 2, pp.121-127.
https://search.emarefa.net/detail/BIM-363418
Modern Language Association (MLA)
Singhal, Manmohan…[et al.]. Synthesis and reducing power assay of methyl semicarbazone derivatives. Journal of Saudi Chemical Society Vol. 18, no. 2 (Apr. 2014), pp.121-127.
https://search.emarefa.net/detail/BIM-363418
American Medical Association (AMA)
Singhal, Manmohan& Paul, Arindam& Singh, Hemendra P.. Synthesis and reducing power assay of methyl semicarbazone derivatives. Journal of Saudi Chemical Society. 2014. Vol. 18, no. 2, pp.121-127.
https://search.emarefa.net/detail/BIM-363418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 126-127
Record ID
BIM-363418