![](/images/graphics-bg.png)
Green tea (Camellia sinesis) ameliorates female Schistosoma mansoni-induced changes in the liver of Balb C mice
Joint Authors
Bin Dajim, Sad M.
Ibrahim, Isam H.
Shati, Ali A.
Adli, Muhammad A.
Ahmad, Usamah M.
Mustafa, Usamah M. S.
Source
Saudi Journal of Biological Sciences
Issue
Vol. 18, Issue 4 (31 Dec. 2011), pp.361-368, 8 p.
Publisher
Publication Date
2011-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
This study was designed to assess the effect of green tea, an aqueous extract of Camellia sinensis, on the oxidative stress, antioxidant defense system and liver pathology of Schistosoma mansoni- infected mice.
Green tea at concentration of 3 % (w / v) was given orally to treated mice as sole source of drinking water from the end of the 4th week to the end of 10th week post-infection ; untreated mice were allowed to drink normal water.
The data of the studied S.
mansoni-infected mice exhibited a suppression of hepatic total antioxidant capacity, superoxide dismutase (SOD), catalase (CAT) activity and glutathione content.
The liver lipid peroxidation was deleteriously elevated in S.
mansoni-infected mice.
The hepatic total protein content, AST and ALT activities were profoundly decreased in the S.
mansoni-infected mice.
Most hepatocytes were damaged and showed abnormal microscopic appearance with aggressive necrosis.
Both total protein and glycogen levels have been greatly reduced as indicated by histochemical examination.
The treatment of S.
mansoniinfected mice with green tea succeeded to suppress oxidative stress by decreasing the lipid peroxides but failed to significantly enhance the antioxidant defense system and deteriorated changes owing to liver damage and necrosis.
In consistence with biochemical data, histopathological and histochemical data indicated that treatment of S.
mansoni-infected mice with green tea could ameliorate hepatocytes thus reduce cellular necrosis and partially restore both total protein and glycogen levels.
Thus, the study concluded that the green tea suppresses the oxidative stress through its constituent with free radicals scavenging properties rather than through the endogenous antioxidant defense system.
American Psychological Association (APA)
Bin Dajim, Sad M.& Shati, Ali A.& Adli, Muhammad A.& Ahmad, Usamah M.& Ibrahim, Isam H.& Mustafa, Usamah M. S.. 2011. Green tea (Camellia sinesis) ameliorates female Schistosoma mansoni-induced changes in the liver of Balb C mice. Saudi Journal of Biological Sciences،Vol. 18, no. 4, pp.361-368.
https://search.emarefa.net/detail/BIM-364600
Modern Language Association (MLA)
Bin Dajim, Sad M.…[et al.]. Green tea (Camellia sinesis) ameliorates female Schistosoma mansoni-induced changes in the liver of Balb C mice. Saudi Journal of Biological Sciences Vol. 18, no. 4 (2011), pp.361-368.
https://search.emarefa.net/detail/BIM-364600
American Medical Association (AMA)
Bin Dajim, Sad M.& Shati, Ali A.& Adli, Muhammad A.& Ahmad, Usamah M.& Ibrahim, Isam H.& Mustafa, Usamah M. S.. Green tea (Camellia sinesis) ameliorates female Schistosoma mansoni-induced changes in the liver of Balb C mice. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 4, pp.361-368.
https://search.emarefa.net/detail/BIM-364600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 367-368
Record ID
BIM-364600