Parathyroid hormone and bone minerals in Sudanese patients with end-stage renal disease : pre and post hemodialysis
Dissertant
al-Amin, Abd al-Salam al-Ubayd Muhammad
Thesis advisor
al-Amin, Abd al-Aziz
Izz al-Din, Umar Musa
University
Omdurman Islamic University
Faculty
Faculty of Medical Laboratory
Department
Clinical Chemistry Department
University Country
Sudan
Degree
Ph.D.
Degree Date
2011
English Abstract
-Background: End-stage renal disease (ESRD) is associated with changes in bone minerals and parathyroid hormone (PTH). Objective: The study aimed to determine serum levels of parathyroid hormone, calcium and phosphate in patients with ESRD and its relation to hemodialysis. Methods: A cross sectional case-control study during the period of study at three hemodialysis units in Omdurman.
One hundred patients with ESRD on regular hemodialysis participated in the study.
Fifty healthy subjects acted as controls.
History and physical findings were documented and blood samples collected for analysis of PTH, bone minerals and other tests. Results: Out of 100 patients, 69 were males and 31 were females.
Age ranged from 15 to 80 years (mean was 47.5 years ± 12.5).
The study found high serum levels of PTH in the patients before dialysis (119.7 pg/ml) compared to controls (31.0 pg/ml), and significant decreased of serum PTH levels after dialysis (61.3 pg/ml).
Serum calcium concentration was low in the patients before dialysis compared to controls (6.8 mg/dl vs.
9.3 mg/dl) and it increased significantly after hemodialysis (7.8 mg/dl).
In contrast the serum phosphate concentration before dialysis was high in patients compared to controls (5.45mg/dl vs.
3.59 mg/dl).
However, it dropped to 3.8 mg/dl after hemodialysis.
The study found no significant correlation between PTH levels and age, cause of ESRD, duration of disease, and frequency of hemodialysis sessions.
However, there was gender difference on PTH levels being lower in males compared to that in females
Main Subjects
Topics
No. of Pages
198
Table of Contents
Table of contents.
Abstract.
Chapter One : Introduction and objectives.
Chapter Two : Literature review.
Chapter Three : Subjects and methods.
Chapter Four : Results.
Chapter Five : Discussion and conclusion.
References.
American Psychological Association (APA)
al-Amin, Abd al-Salam al-Ubayd Muhammad. (2011). Parathyroid hormone and bone minerals in Sudanese patients with end-stage renal disease : pre and post hemodialysis. (Doctoral dissertations Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364710
Modern Language Association (MLA)
al-Amin, Abd al-Salam al-Ubayd Muhammad. Parathyroid hormone and bone minerals in Sudanese patients with end-stage renal disease : pre and post hemodialysis. (Doctoral dissertations Theses and Dissertations Master). Omdurman Islamic University. (2011).
https://search.emarefa.net/detail/BIM-364710
American Medical Association (AMA)
al-Amin, Abd al-Salam al-Ubayd Muhammad. (2011). Parathyroid hormone and bone minerals in Sudanese patients with end-stage renal disease : pre and post hemodialysis. (Doctoral dissertations Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364710
Language
English
Data Type
Arab Theses
Record ID
BIM-364710
