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Complement and hyper acute rejection
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 3 (30 Jun. 2009), pp.362-369, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-06-30
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Organ transplantation has been a major development in clinical medicine but its success has been marred by the immune system's capacity to respond to "non-self" cells and tissues.
A full molecular understanding of this mechanism and the myriad triggers for immune rejection is yet to be elucidated.
Consequently, immunosuppressive drugs remain the mainstay of post-transplant management; however, these interventions have side effects such as increased incidence of cancer, post-transplant lymphoproliferative disorders, susceptibility to infection if not managed appropriately and the inconvenience to the patient of lifelong treatment.
Novel therapeutic approaches based on molecular understanding of immunological processes are thus needed in this field.
The notion that factors influencing successful transplants might be of use as therapeutic approaches is both scientifically and medically appealing.
Recent developments in the understanding of successful transplants are expected to provide new opportunities for safer transplantation.
This article reviews the present understanding of the molecular basis of rejection and the role of complement in this process as well as the possibility of generating "intelligent" therapy that better target crucial components of hyperacute rejections.
American Psychological Association (APA)
al-Rabiah, Muhammad W. O.. 2009. Complement and hyper acute rejection. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 3, pp.362-369.
https://search.emarefa.net/detail/BIM-36637
Modern Language Association (MLA)
al-Rabiah, Muhammad W. O.. Complement and hyper acute rejection. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 3 (Sep. 2009), pp.362-369.
https://search.emarefa.net/detail/BIM-36637
American Medical Association (AMA)
al-Rabiah, Muhammad W. O.. Complement and hyper acute rejection. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 3, pp.362-369.
https://search.emarefa.net/detail/BIM-36637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 367-369
Record ID
BIM-36637