Comparison of 24-jour urinary protein and -to-creatinine ratio in the assessment of proteinuria
Joint Authors
Wahbi, Ayman M.
Uways, Muhammad H.
al-Sharif, Muhammad E.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 3 (30 Jun. 2009), pp.443-447, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-06-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
- Examinations
- Kidneys
- Diseases
- Pathology
- Urinary protein
- Urine analysis
- Jordan
- Semiotics
- Creatinine
- Clinical chemistry
Abstract EN
To determine the correlation between protein-to-creatinine ratio (PCR) and 24-hour urinary protein (UP), we measured proteinuria in 68 patients attending the nephrology clinic at Jordan University Hospital by 24-hour urine protein excretion and protein-to-creatinine ratio.
The cutoff values for spot urine protein-to-creatinine ratio in predicting 24-hour protein "threshold" excretion of 0.5, 1.0 and 3.5 g / day were determined using receiver operating characteristic curves.
A very good correlation (r= 0.832, P< 0.0001) was found between spot urine protein-to-creatinine ratio and 24-hour urine protein excretion.
Bland-Altman plot showed the two tests had reasonable limits of agreement at low level of protein excretion but the limits became wider as the protein excretion increased.
For protein excretion < 2.0 g / day, the limits of agreement of spot urine (PCR) and (UP) were +1.48 and -1.2 g / day.
The spot urine protein-to-creatinine ratios of 0.72 (sensitivity 0.97; specificity 1.0), 1.2 (0.97; 0.89) and 3.23 (1.0; 0.86) mg / mg reliably predicted 24-hour urine total protein equivalent "thresholds" of 0.5, 1.0 and 3.5 g / day, respectively.
We conclude that the protein-to-creatinine ratio in spot urine specimens is an accurate, convenient, and reliable method to estimate the protein excretion in urine.
However, the protein-to-creatinine ratio will likely be within clinically acceptable limits only when proteinuria is at reasonably low levels.
American Psychological Association (APA)
Wahbi, Ayman M.& Uways, Muhammad H.& al-Sharif, Muhammad E.. 2009. Comparison of 24-jour urinary protein and -to-creatinine ratio in the assessment of proteinuria. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 3, pp.443-447.
https://search.emarefa.net/detail/BIM-36823
Modern Language Association (MLA)
Wahbi, Ayman M.…[et al.]. Comparison of 24-jour urinary protein and -to-creatinine ratio in the assessment of proteinuria. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 3 (Sep. 2009), pp.443-447.
https://search.emarefa.net/detail/BIM-36823
American Medical Association (AMA)
Wahbi, Ayman M.& Uways, Muhammad H.& al-Sharif, Muhammad E.. Comparison of 24-jour urinary protein and -to-creatinine ratio in the assessment of proteinuria. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 3, pp.443-447.
https://search.emarefa.net/detail/BIM-36823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 446-447
Record ID
BIM-36823