Electrophysiological study of peripheral nerves in children with acute lymphoblastic leukemia
Joint Authors
Umar, Karim A.
Hisab, Huda
Imam, Muhammad H.
Abd al-Ghani, Hiyam M.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 40, Issue 2 (30 Jun. 2013), pp.63-69, 7 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2013-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells affecting both children and adults.
Chemotherapy-induced peripheral neurotoxicity is an important side effect of several chemotherapeutic agents.
Objectives The aim of this study was to detect the presence and types of peripheral neuropathy (PN) in newly diagnosed children with ALL, before and after the phase of induction of remission.
Methodology A total of 24 children newly diagnosed with ALL were enrolled into the study (group I).
They were subjected to clinical and electrodiagnostic assessments to examine the integrity of the peripheral nervous system before and after receiving chemotherapeutic agents.
Ten apparently healthy children served as controls (group II).
Results Electrodiagnostic assessment revealed that 16 children (67%) had no documented PN, whereas eight (33%) had PN.
Of these eight children, two (8.3%) were proven to have chemotherapy-induced PN, four (16.6%) had subclinical chemotherapy-induced PN, and two (8.3%) had subclinical PN due to ALL.
Of the eight children with PN, five (62.5%) had an axonal pattern, one (12.5%) had a demyelinating pattern, and two (25%) had a mixed axonal demyelinating pattern of affection.
In general, the affection of peripheral motor nerves was greater compared with sensory nerve affection.
Conclusion Chemotherapeutic agents used in the treatment of ALL (phase I: induction of remission) proved to have neurotoxic effects on peripheral nerves.
In most children, the PN was subclinical.
American Psychological Association (APA)
Ibrahim, Ibrahim K.& Hisab, Huda& Imam, Muhammad H.& Abd al-Ghani, Hiyam M.& Umar, Karim A.. 2013. Electrophysiological study of peripheral nerves in children with acute lymphoblastic leukemia. Egyptian Rheumatology and Rehabilitation،Vol. 40, no. 2, pp.63-69.
https://search.emarefa.net/detail/BIM-380907
Modern Language Association (MLA)
Hisab, Huda…[et al.]. Electrophysiological study of peripheral nerves in children with acute lymphoblastic leukemia. Egyptian Rheumatology and Rehabilitation Vol. 40, no. 2 (Apr. / Jun. 2013), pp.63-69.
https://search.emarefa.net/detail/BIM-380907
American Medical Association (AMA)
Ibrahim, Ibrahim K.& Hisab, Huda& Imam, Muhammad H.& Abd al-Ghani, Hiyam M.& Umar, Karim A.. Electrophysiological study of peripheral nerves in children with acute lymphoblastic leukemia. Egyptian Rheumatology and Rehabilitation. 2013. Vol. 40, no. 2, pp.63-69.
https://search.emarefa.net/detail/BIM-380907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 69
Record ID
BIM-380907