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Antibiotic susceptibility patterns and molecular epidemiology of metallo-β-lactamase producing pseudomonas aeruginosa strains isolated from burn patients
Joint Authors
Giammanco, Giovanni M.
Japoni, Aziz
Anvarinejad, Mujtaba
Farshad, Shohreh
Rafaatpour, Nur al-Din
Alipour, Ibrahim
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 5 (31 May. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-05-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Failure in the treatment of burn patients infected with Pseudomonas aeruginosa could happen as a result of the acquisition of antibiotic resistance, including carbapenems.
Objectives : The aim of the present study was to investigate the phenotypic and genotypic characteristics of the Pseudomonas aeruginosa strains, isolated from burn patients.
Patients and Methods : During a 12 month period, in this cross-sectional study, two hundred seventy strains of Pseudomonas aeruginosa were isolated from the burn patients in Ghotbeddin Burn Hospital, Shiraz, Iran.
Screening for the carbapenem resistance in the isolates was carried out by the E test method.
Sensitivity patterns of metallo-β-lactamase (MβLs) producing strains of pseudomonas to eleven antibiotics were determined by the mentioned method.
The epidemiological associations of these strains were determined by Pulsed-field gel electrophoresis (PFGE).
Results : Of the 270 strains, 60 (22.2 %) were resistant to imipenem and meropenem, classified as MβLs producing.
MβLs producing strains of pseudomonas were completely resistant to five tested antibiotics while their sensitivities to the three most effective antibiotics including ceftazidime, amikacin and ciprofloxacin were 23.4 %, 6.7 % and 1.7 %, respectively.
In PFGE, 37 patterns from the genome of Pseudomonas aeruginosa were observed.
Majority of the strains (43 ; 71.6 %) exhibited more than 80 % similarity, based on the drawn dendrogram.
Conclusions : According to the results, none of the tested antibiotics is safe to prescribe.
As PFGE revealed, a limited number of Pseudomonas aeruginosa types are predominant in the hospitals which infect the burn patients.
American Psychological Association (APA)
Japoni, Aziz& Anvarinejad, Mujtaba& Farshad, Shohreh& Giammanco, Giovanni M.& Rafaatpour, Nur al-Din& Alipour, Ibrahim. 2014. Antibiotic susceptibility patterns and molecular epidemiology of metallo-β-lactamase producing pseudomonas aeruginosa strains isolated from burn patients. Iranian Red Crescent Medical Journal،Vol. 16, no. 5, pp.1-6.
https://search.emarefa.net/detail/BIM-385690
Modern Language Association (MLA)
Japoni, Aziz…[et al.]. Antibiotic susceptibility patterns and molecular epidemiology of metallo-β-lactamase producing pseudomonas aeruginosa strains isolated from burn patients. Iranian Red Crescent Medical Journal Vol. 16, no. 5 (May. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-385690
American Medical Association (AMA)
Japoni, Aziz& Anvarinejad, Mujtaba& Farshad, Shohreh& Giammanco, Giovanni M.& Rafaatpour, Nur al-Din& Alipour, Ibrahim. Antibiotic susceptibility patterns and molecular epidemiology of metallo-β-lactamase producing pseudomonas aeruginosa strains isolated from burn patients. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 5, pp.1-6.
https://search.emarefa.net/detail/BIM-385690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-385690