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Correlation between the levels of sE- seleetin and ige and the severity of atopie dermatitis (AD)
Other Title(s)
دراسة الارتباط بين مستوى ال أي-سيليكتين الذائب في الدم و شدة مرض حساسية الجلد (التأتب)
Joint Authors
al-Jawhari, Ahmad Majdi
al-Akhras, Atif Ibrahim
Abu Bakr, Rabi Abu al-Majd
Rizq, Jilan Abd al-Razzaq
Ayyadah, Mustafa Muhammad Kamil
Source
Suez Canal University Medical Journal
Issue
Vol. 5, Issue 1 (31 Mar. 2002), pp.7-16, 10 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2002-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Atopic dermatitis is a chronically relapsing pruritic skin condition based on multifactorial genetic predisposition.
sE-selectin may be the most sensitive and useful ' in monitoring the activity and clinical course of AD.
Studies support sE-selectin as a ٨١^^٢ for AD So determination of the level of adhesion molecules particularly E seleetin and there corcelation with the activity and severity of AD may help in understanding of these disease and may lead to new strategies in treatment.
Aim of the work: Estimation of the serum level of sE-selectin, !gE and correlation of their levels with the severity of the disease in AD patients.
Methods and subjects: Thirty patients of both sexs with atopic dermatitis (mean age 6.5±2.6),Ten healthy, sex-matched subjects (mean age (6.7±3.1) were included in this analytic study.
None of the patients W'ere treated with systemic steroids.
Twenty eight of the patients were treated with local srteroid ointment, and twenty-three were taking antihistamine drugs.
Total IgE was measured by using Soluble E-seJectin was determined by sandwich ELJSA.
Results: Serum sE-selectin and IgE of AD patients was significantly greater than that of the normal control subjects and correlate with the severity of atopic dermatitis.
The levels of sE-selectin correlate with IgE levels.
Conclusion: Although sE-selectin is not specific for AD, It is a useful immunological marker tor monitoring disease severity.
Further studies are needed to assess the role of sE-selectin in atopic dermatitis to help understanbding its pathogenesis and if sE-selectin could be used as indicator for the prognosis of AD and its role in the stratigy of AD treatment.
American Psychological Association (APA)
Abu Bakr, Rabi Abu al-Majd& Rizq, Jilan Abd al-Razzaq& al-Akhras, Atif Ibrahim& Ayyadah, Mustafa Muhammad Kamil& al-Jawhari, Ahmad Majdi. 2002. Correlation between the levels of sE- seleetin and ige and the severity of atopie dermatitis (AD). Suez Canal University Medical Journal،Vol. 5, no. 1, pp.7-16.
https://search.emarefa.net/detail/BIM-393451
Modern Language Association (MLA)
Abu Bakr, Rabi Abu al-Majd…[et al.]. Correlation between the levels of sE- seleetin and ige and the severity of atopie dermatitis (AD). Suez Canal University Medical Journal Vol. 5, no. 1 (Mar. 2002), pp.7-16.
https://search.emarefa.net/detail/BIM-393451
American Medical Association (AMA)
Abu Bakr, Rabi Abu al-Majd& Rizq, Jilan Abd al-Razzaq& al-Akhras, Atif Ibrahim& Ayyadah, Mustafa Muhammad Kamil& al-Jawhari, Ahmad Majdi. Correlation between the levels of sE- seleetin and ige and the severity of atopie dermatitis (AD). Suez Canal University Medical Journal. 2002. Vol. 5, no. 1, pp.7-16.
https://search.emarefa.net/detail/BIM-393451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14-15
Record ID
BIM-393451