Evaluation of antioxidant, antimicrobial and cytotoxicity of Alcea kurdica alef

Abstract EN

The purpose of this study is to evaluate the aqueous extract of Alcea kurdica Alef for antioxidant and antimicrobial activity as well as potential toxicity.

Antioxidant activities were evaluated using 1,1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging and Ferric Reducing Antioxidant Power (FRAP) reducing capacity assays as well as total phenolic compounds (TPC).

Antimicrobial activity was assessed against some Gram-positive and Gram-negative bacteria, yeasts and filamentous fungi using the agar dilution method.

The plant extract was also assessed for in-vitro toxicity using the Promega Cell Titer 96 AQueous Non-Radioactive Cell Proliferation (MTS) assay.

The aqueous extract of A.

kurdica demonstrated potent free radical scavenging activity of 64% ± 1.64% and ferric reduction capacity of 2955.0 ± 0.04 mmol/g, as well as having 88.0 ± 0.002 mg gallic acid equivalents /gram plant extract.

The aqueous extract of A.

kurdica had modest antimicrobial activity against most tested microorganisms.

Moreover, the plant extract did not have any toxic effects on human lung fibroblasts.

Based on these findings, we conclude that A.

kurdica may be utilized to prevent the growth of some microorganisms.

The plant constituents behind these effects are the antioxidants and phenols.

Further studies are needed to evaluate the therapeutic utility of A.

kurdica extracts as antimicrobial agents.