Evaluation of enzymatic and non enzyme antioxidants from sera of asthmatic patients in Hilla City

Abstract EN

The study was conducted on healthy subjects [control (n = 39), male = 19, females = 20] and asthmatic patients who were treated with inhaled salbutamol [patients (n = 41), male = 21, females = 20] and asthmatic patients who were treated with Montelukast drugs [patients (n = 37), male = 19 , females = 18].The samples of patients were obtained from Asthma and Allergy Center in Hilla city.

The study was performed at the laboratory of biochemistry department in college of medicine, University of Babylon.

Measurements the total antioxidant capacity (TAC), total protein and Superoxide dismutase (SOD) enzyme activities, also Se, Zn and Cu levels were measured by flame atomic absorption spectrophotometry (FAAS), in sera.

The results revealed that highly significant decreasing in the TAC and SOD activity in sera of asthmatic patients (p < 0.01) in comparison with that of controls subjects.

Serum levels of Zn, Cu, and Se were significantly different (p < 0.001 for all) in patients when compared with healthy subjects.