Assessment of circulating biochemical markers and antioxidative status in acute lymphoblastic leukemia (ALL)‎ and acute myeloid leukemia (AML)‎ patients

Abstract EN

Various circulating biochemical markers are indicators of pathological state in leukemia and its subtypes.

Increased oxidative stress and decreased antioxidant factors portray clear image associated with malignancies during subtypes of leukemia.

In this research work we investigated the inter-relationship among the subtypes of leukemia with circulating biochemical markers and oxidative stress in the Pakistani population.

This research work was conducted on a total number of 70 subjects in which 20 were control participants and 50 were suffering from leukemia and divided into two subtypes (ALL and AML).

Various circulating biomarkers were investigated including hematological, hepatic and renal profiles as well as oxidative stress markers, electrolytes and vitamins C and E.

Results show that vitamin E was found to be decreased in diseased sub-types (P < 0.05).