Clinical biomarkers in sickle cell disease

Abstract EN

Sickle cell disease (SCD) is a hereditary blood disorder caused by a single gene.

Various blood and urine biomarkers have been identified in SCD which are associated with laboratory and medical history.

Biomarkers have been proven helpful in identifying different interconnected disease-causing mechanisms of SCD, including hypercoagulability, hemolysis, inflammation, oxidative stress, vasculopathy, reperfusion injury and reduced vasodilatory responses in endothelium, to name just a few.

However, there exists a need to establish a panel of validated blood and urine biomarkers in SCD.

This paper reviews the current contribution of biochemical markers associated with clinical manifestation and identification of sub-phenotypes in SCD.