A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury
Joint Authors
du Toit, Lisa C.
Pillay, Viness
Ramburrun, Poornima
Choonara, Yahya E.
Kumar, Pradeep
Bijukumar, Divya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Peripheral nerve regeneration strategies employ the use of polymeric engineered nerve conduits encompassed with components of a delivery system.
This allows for the controlled and sustained release of neurotrophic growth factors for the enhancement of the innate regenerative capacity of the injured nerves.
This review article focuses on the delivery of neurotrophic factors (NTFs) and the importance of the parameters that control release kinetics in the delivery of optimal quantities of NTFs for improved therapeutic effect and prevention of dose dumping.
Studies utilizing various controlled-release strategies, in attempt to obtain ideal release kinetics, have been reviewed in this paper.
Release strategies discussed include affinity-based models, crosslinking techniques, and layer-by-layer technologies.
Currently available synthetic hollow nerve conduits, an alternative to the nerve autografts, have proven to be successful in the bridging and regeneration of primarily the short transected nerve gaps in several patient cases.
However, current research emphasizes on the development of more advanced nerve conduits able to simulate the effectiveness of the autograft which includes, in particular, the ability to deliver growth factors.
American Psychological Association (APA)
Ramburrun, Poornima& Kumar, Pradeep& Choonara, Yahya E.& Bijukumar, Divya& du Toit, Lisa C.& Pillay, Viness. 2014. A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-448247
Modern Language Association (MLA)
Ramburrun, Poornima…[et al.]. A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-448247
American Medical Association (AMA)
Ramburrun, Poornima& Kumar, Pradeep& Choonara, Yahya E.& Bijukumar, Divya& du Toit, Lisa C.& Pillay, Viness. A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-448247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448247